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Effect of Anemic Hypoxia on Erythropoiesis of Normal and Uremic Dogs With or Without Kidneys^1,2,

Belgium

ABSTRACT

The effect of acute anemic hypoxia on erythropoiesis has been compared in normal and uremic dogs. Uremia was achieved by nephrectomy or ureteral ligation or implantation of the ureter in the iliac vein. Erythropoiesis was measured 3 days before and 3, 5 and 7 days after bleedings and surgey by plasma iron turnover, absolute reticulocyte counts and marrow normoblast percentages. Bilateral nephrectomy abolished the erythropoietic response which normally occurs after acute anemic hypoxia. In uremic dogs still having one or both kidneys after a transient increase, a decrease in erythropoiesis was observed. These results suggest that in the dog, there is no emergency mechanism stimulating erythropoiesis independent of the kidney. No definite conclusions can be drawn concerning the role of uremia in the lack of normal response to bleedings of uremic dogs still having kidneys. Sheep erythropoietin is able to stimulate erythropoiesis in the bilaterally nephrectomised dog.

FOOTNOTES

¹ (Laboratoire de Médecine Expérimentale et Laboratoire de Biologie Clinique. Université Libre de Bruxelles et Fondation Médicale Reine Elisabeth)

² Aided by Grants Fonds Paul Govaerts and Lekime-Ropsy.