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Immunological Removal of Circulating I¹³¹-Labeled Rabbit Antibody to Rat Fibrinogen in Normal and Tumor-Bearing Rats^1,2,

Rochester, New York

ABSTRACT

Purified I¹³¹ rabbit antibody to rat fibrinogen has been substantially removed from circulation using goat antiserum to rabbit gamma globulin. Subsequent studies on I¹³¹ activity in organs of such rates show considerable immediate deposition of the radioactivity in the liver and somewhat less in the spleen; this is eliminated in 6–12 hours. I¹³¹ determinations on Murphy-Sturm tumors in such immunologically treated animals demonstrate little, if any, loss of tumor-deposited I¹³¹ for the first 24 hours. The bearing of these results on scintillation scanning techniques for tumors and thrombi are discussed.

FOOTNOTES

¹ Department of Radiation Biology, University of Rochester, School of Medicine and Dentistry, Rochester, New York.

² This paper is based on work performed under contract with the United States Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, New York, and was also supported by U.S.P.H.S. Research Grant CA 6982.

³ Presented, in part, at the Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, April, 1963.