HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Taplin, G. V. Articles by Kaplan, H. S. Search for Related Content PubMed PubMed Citation Articles by Taplin, G. V. Articles by Kaplan, H. S.

Suspensions of Radioalbumin Aggregates for Photoscanning the Liver, Spleen, Lung and Other Organs^1,2,3

Los Angeles and Torrance, California

ABSTRACT

Current methods of preparing small and large size suspensions of radioalbumin aggregates by heat treatment and pH adjustment are presented. The small size colloidal suspensions (10–20 mµ) are shown to be superior to other agents for liver-spleen scanning. Radiation exposure to these organs is minimized and the albumin suspensions can be prepared with relative ease and simplicity. Also the heart, stomach and salivary glands may be clearly visualized by photoscanning with this material. The techniques and physiological basis for performing and interpretating scans of these organs are described. Their diagnostic value is illustrated.

The preparation and physiological basis for using large size suspensions of the same material for visualization of the lungs is presented along with scans typical of those produced with suspensions of each of two size ranges (2.5 and 15 µ). The smaller size is preferable because of far less probability of capillary embolization. Trials in patients with lung cancer will be initiated after additional animal studies ensure the complete safety of the test procedure.

FOOTNOTES

¹ With technical assistant of M. L. Griswold, R. P. DiVeroly and M. Yamaguchi.

² These studies were supported by Contract AT(04-1)-GEN-12 between the U.S. Atomic Energy Commission and the University of California at Los Angeles, and by a grant-in-aid from E. R. Squibb and Sons, Radiopharmaceutical Division.

³ From the Laboratory of Nuclear Medicine and Radiation Biology of the Department of Biophysics—Nuclear Medicine, and the Department of Radiology, School of Medicine, University of California at Los Angeles; and from the Nuclear Medicine Division of the Department of Radiology, the Los Angeles County Harbor General Hospital, Torrance, California.