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Lanthanum-140 as a Measure of the Completeness of Stool Collections Demonstration of Delayed Excretion of Iron-59^1,2

Oak Ridge, Tennessee

ABSTRACT

Lanthanum-140, as an unabsorbable tracer given with an oral dose of other substances, can be used to verify the completeness of stool collections for gastrointestinal absorption tests. However, when collections are incomplete, the proportion of lanthanum-140 lost cannot be used to calculate the loss of unabsorbed iron-59 because the rates of passage through the intestinal tract are different. A distinct retardation of iron-59 excretion was observed. Lanthanum-140 is of use in studying this phenomenon, which probably can be attributed to exfoliation of epithelial cells containing iron taken up from the intestinal tract.

FOOTNOTES

¹ From the Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee, under contract with the United States Atomic Energy Commission.

² Presented in part at the 10th Annual Meeting of the Society of Nuclear Medicine, Montreal, Canada, June 29, 1963.