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Labeling of Human Globulin With I¹²⁴ For Positron Scanning of Neoplasms^1,2

Winston-Salem, North Carolina, Upton, New York and Boston, Massachusetts

ABSTRACT

Normal and aberrant gamma globulin have been labeled by I¹²⁴ produced by alpha particle bombardment of antimony in a 60-inch cyclotron. Localization of the labeled globulin in primary brain neoplasms has been demonstrated by positron scanning. It appears possible by this procedure to investigate in various tissues and organs in man sites of catabolism of similarly labeled proteins.

FOOTNOTES

¹ From the Department of Pathology, Bowman Gray School of Medicine, Winston-Salem, North Carolina; the Medical and Nuclear Engineering Departments, Brookhaven National Laboratory, Upton, New York; Physics Research Laboratory and Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.

² This research was supported by the United States Atomic Energy Commission and an Institutional Grant of the American Cancer Society.