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Early Diagnosis of Metastatic Bone Cancer By Photoscanning With Strontium-85^1,2

Philadelphia

ABSTRACT

Photoscans of bone utlizing 50 µc of strontium-85 have been made in 90 patients with cancer, with proven or suspected metastases to bone. In 11 patients the scan was positive and the x-ray negative, and in 75 other patients there was good agreement between the scan and the roentgenogram. The scan, however, frequently showed greater involvement than was apparent on x-ray. These results were confirmed by bone biopsy in 14 patients. Phantom studies were carried out which indicated that there is good correlation between the scan and known isotopic volumes within bone. Bone tissue counts of radiostrontium content were also correlated with biopsy findings and lend further support to the validity of the method.

It is therefore clear that the Sr-⁸⁵ photoscan cna detect early metastatic cancer to bone prior to observable roentgenographic changes. Not only have these scans been of value in diagnosis, but they have allowed the radiation therapist to plan treatment portals more effectively.

FOOTNOTES

¹ Presented at the 10th Annual Meeting, Society Nuclear Medicine, Montreal, Canada, June 27, 1963.

² From the Department of Radiology (Nuclear Medicine and Radiation Therapy), Albert Einstein Medical Center, Northern Division, Philadelphia, Pennsylvania.