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Diagnosis of Pancreatic Disease by Photoscanning^1,2,3,

Ann Arbor, Michigan

ABSTRACT

The results of pancreas photoscans performed with Se⁷⁵ selenomethionine in 37 patients have been reviewed in an attempt to establish the reliability and usefulness of the test in the diagnosis of pancreatic disease. The pancreas was well visualized in 12 out of 15 normal patients. In eight of eleven patients with pancreatitis and in seven of eleven patients with pancreatic or peripancreatic carcinoma, abnormalities consisting of diffuse decrease in concentration or local reduction in uptake were observed. The procedure proved useful in evaluating patients suspected of having pancreatic carcinoma and in the diagnosis of pancreatitis. It was also useful in excluding pancreatic abnormality in patients with metastatic neoplasm, although it seems likely that small lesions that are peripherally placed could be missed by this technique.

Certain difficulties with interpretation, brought about by variations in the normal size, shape and concentrating ability of the pancreas and interference from radioactivity in the liver were encountered and are expected to limit the diagnostic accuracy of the procedure. In spite of its limitations at the present time, the technique offers a simple method for visualizing the pancreas without an operation and deserves further application.

FOOTNOTES

¹ From the departments of Internal Medicine and Surgery and the Nuclear Medicine Unit, University of Michigan Medical Center, Ann Arbor,Michigan.

² Supported in part by a grant from the United States Public Health Service, and the Nuclear Medicine Research Fund.

³ Presented at the 10th annual meeting of the Society of Nuclear Medicine, Montreal, Canada, June 27, 1963.

⁴ Present address, Division of Nuclear Medicine, University of Texas Medical Center, Galveston, Texas.

⁵ Present address, Division of Gastroenterology, Scripps Clinic and Research Foundation, La Jolla, California.

⁶ John & Mary Markle Scholar in Academic Medicine; USPHS Career Development Awardee AMK3-13,702.