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Age Differences in Routine Scans of Human Brain with Arsenic-74

Queens Village, New York and Newark, New Jersey

ABSTRACT

Print counts were made over a frontal area of the head on records obtained during positron scanning with arsenic 74 in 29 patients. Counts were significantly higher (p< 0.001) for 12 patients aged 60 and over in a group of 26 without recognized disease of liver or kidney. Highest counts were obtained in 2 patients with cirrhosis of the liver.

Possible explanations for the finding are discussed, including differences in extracerebral tissue mass, cerebral parenchymal volume, blood volume, total extra-cellular fluid cerebral volume, and clearance capability by liver and kidney. It is concluded that impaired clearance capability probably underlies the difference, and that this factor should be controlled if isotopes are employed to study cerebral blood flow or metabolism.

FOOTNOTES

¹ Creedmoor Institute for Psychobiologic Studies, Queens Village 27, New York.

² Presbyterian Hospital Unit of United Hospitals of Newark, 27 South Ninth Street, Newark, New Jersey.