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The Journal of Nuclear Medicine Vol. 5 No. 2 125-133
© 1964 by Society of Nuclear Medicine
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The Use of Radioactive Isotopes to Study the Hemodynamic Pattern, Function and Morphology of the Liver in Hepato-Splenic Bilharziasis (Schistosomiasis)1

Muhammad Abdel Razzak, M.D. 2,3 

ABSTRACT

Patients having hepato-splenic bilharziasis (schistosomiasis) can be classified into 4 grades: preclinical; mild; cases with oesophogeal varices indicating the presence of portal hypertension and those having ascites.


Figure 1

Radioactive isotopes were used to study the hemodynamic pattern, function and morphology of the liver in a group of 60 patients suffering from this disease.

The radioisotopic technique applied showed that the hemodynamics, cell function and morphology of the liver in grade I cases were normal. In the second grade, there was a slight diminution in hepatic blood flow (HBF), definite prolongation of cardioportal circulation time (CPCT) and some change in morphology as shown by photoscanning. Patients having oesophogeal varices without ascites had marked reduction in HBF and occasionally showed evidence of parenchymal affection. In the same group of cases, the CPCT was prolonged and scan picture distorted. Lastly, those with ascites had diminished HBF and marked affection of liver parenchyma. The photoscan was severely distorted and shrunken and CPCT was variable. However, it should be remembered that these findings were not constant in all cases from the same grade.

FOOTNOTES

1 This work was partly presented at the Tenth Annual Meeting, Society of Nuclear Medicine, June 27, 1963, Montreal, Canada.

2 Medical Unit and Section of Nuclear Medicine, Faculty of Medicine, Cairo University.

3 Medical Unit of Atomic Energy Establishment, U.A.R.






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