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The Journal of Nuclear Medicine Vol. 5 No. 12 920-928
© 1964 by Society of Nuclear Medicine
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The Uptake of Differentially Coupled 74As-Arsano-Poly-L-Lysine in Tumor-Bearing Mouse Tissues1

John L. Mego, Ph.D. and J. Donald McQueen, M.D.2

Baltimore

ABSTRACT

74As-arsanilate was coupled to poly-L-lysine with various ratios of arsanilate to lysine groups in the reactions. The resulting compounds were dialyzed and injected into tumor-bearing mice; and the concentrations were measured in blood, tumor, kidney and liver up to four hours after injection. Lightly coupled preparations (11 to 13 arsanilate groups per 30 lysine residues) were most rapidly cleared from the blood stream and showed the highest uptake by liver and kidneys with relatively low concentrations in tumor. Increasing the number of arsanilate groups resulted in greater uptake by tumor and less rapid clearance from the blood stream with a corresponding decrease in uptake by kidneys and liver. The uptake into tumor, therefore, was directly related to the concentration in the blood stream. This finding appears to be of value in the preparation of potential scanning agents, macromolecular chemotherapeutic agents and similar materials.

FOOTNOTES

1 Supported by Contract AT (30-1) 2182, U. S. Atomic Energy Commission, and Grant No. C-3265, National Cancer Institute, National Institutes of Health. Part of the material in this paper was presented at the American Chemical Society, Division of Biological Chemistry, 146th National Meeting, Denver, Colorado, January 19–24, 1964.

2 Division of Neurological Surgery, Baltimore City Hospitals, and The Johns Hopkins University School of Medicine.






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Copyright © 1964 by the Society of Nuclear Medicine.