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The Journal of Nuclear Medicine Vol. 5 No. 12 895-900
© 1964 by Society of Nuclear Medicine
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Peripheral Appearance of Radiolabeled Albumin and an Alkylating Agent During Regional Brain Perfusion1

Richard P. Spencer, M.D., Ph.D., James B. D. Mark, M.D. and Stevenson Flanigan, M.D.2

New Haven, Connecticut

ABSTRACT

During a regional brain perfusion, albumin-131I added to the perfusing fluid rapidly decreased in activity and appeared in the peripheral circulation. When triethylene thiophosphoramide-S35 was present in the perfusing fluid, about 14 per cent appeared in the peripheral circulation within one minute. The concentration of radioactivity in the perfusing fluid, as a function of time, was described by an hyperbola. These results cast doubt on the efficacy of carrying regional brain perfusion beyond four or five minutes.

FOOTNOTES

1 Supported by USPHS Research Grants Nos. CA 6519 and HD 00411.

2 From the Departments of Radiology and Surgery, Yale University School of Medicine, New Haven, Connecticut.







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Copyright © 1964 by the Society of Nuclear Medicine.