HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Nofal, M. M. Articles by Beierwaltes, W. H. Search for Related Content PubMed PubMed Citation Articles by Nofal, M. M. Articles by Beierwaltes, W. H.

Persistent Chromosomal Aberrations Following Radioiodine Therapy¹

Ann Arbor

ABSTRACT

A statistically significant increased incidence of chromosomal abnormalities both in count and morphology was observed acutely and to a lesser extent chronically after radioiodine therapy for hyperthyroidism. These abnormalities were detected as early as hour after the therapy dose and were found to persist for at least 14 years after the treatment.

The incidence and severity of abnormalities were greater after the larger treatment doses of I¹³¹ for thyroid carcinoma, and in the period shortly after treatment. No hematological phenomena accompanied the chromosomal abnormalities.

Apparently, no chromosomal aberrations could be attributed to the use of antithyroid drugs or to the thyroid status at the time of the study. Further work is in progress to evaluate other factors which might affect the chromosomal analysis.

FOOTNOTES

¹ This investigation was supported by USPHS Research Grant No. 5T1 CA-5134-02 and No. CA-05174-04 from the National Cancer Institute.

² From the Department of Internal Medicine (Nuclear Medicine Unit) University of Michigan Medical School, Ann Arbor, Michigan.