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An Exploratory Study of Fe⁵⁹-Labeled Ferrocene As a Carrier in Tracer Techniques¹

Atlanta, Georgia

ABSTRACT

The distribution of Fe⁵⁹ in the rat following gastric administration of labeled ferrocene has been studied. Within twelve days, over half of the administered activity was recovered in urine, and about 10 per cent in feces. Fat initially contained the highest concentrations of Fe⁵⁹, but these rapidly decreased to levels of less than one per cent of those originally seen. Liver activity increased for two days to a concentration higher than that observed in fat; thereafter, liver contained a relatively constant 21 per cent of the administered activity. The Fe⁵⁹ concentration in whole blood increased throughout the experimental period, while that of the plasma rapidly decreased to essentially zero values. However, at the end of twelve days the total Fe⁵⁹ content of whole blood was still less than 3 per cent of the administered activity.

These data suggest that labeled compounds of the ferrocene type have potential applications in the field of nuclear medicine.

FOOTNOTES

¹ From the Radioisotope Service, Veterans Administration Hospital, Atlanta, Georgia, and the Departments of Biochemistry, Medicine and Chemistry, Emory University, Atlanta, Georgia.