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An Approach to the Scanning of Pulmonary Infarcts^1,2,

Winston-Salem, North Carolina

ABSTRACT

1. A simple embolus technique for producing pulmonary infarcts in mongrel dogs is described. It was successful in 43 of 44 instances where the embolus could be located within the pulmonary artery system.

2. Three radiopharmaceuticals viz. Cr⁵¹ tagged red blood cells, I¹³¹ human serum albumin and Hg²⁰³ chlormerodrin were evaluated as to their possible efficiency in detecting such infarcts. Chlormerodrin was the only one found to be promising.

3. Successful scans of the pulmonary infarct outside of the chest were obtained. No attempt was made to scan the lungs inflated or within the chest.

4. Hg²⁰³ chlormerodrin is not likely to be a satisfactory compound for detecting pulmonary infarcts in clinical practice, particularly in regard to scanning the lower lobes of the lungs, due to interference from liver, spleen and renal activity.

5. The described experimental technique is probably satisfactory for initial screening of other radiopharmaceuticals for possible use in the detection of pulmonary infarction.

FOOTNOTES

¹ Departments of Radiology and Surgery, Bowman Gray School of Medicine.

² This project was supported by a grant from the Fluid Research Funds of the Bowman Gray School of Medicine.

³ Fellow, American Cancer Society.

⁴ Senior Investigator in Clinical Research, N.C. Heart Association.

⁵ Research Fellow, National Institutes of Health (Heart Institute).