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Journal of Nuclear Medicine Vol. 49 No. Suppl_2 180S-195S
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.107.045971

Noninvasive Imaging of Cell-Mediated Therapy for Treatment of Cancer

Elizabeth J. Akins1 and Purnima Dubey2

1 Section on Molecular Medicine, Department of Internal Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina; and 2 Department of Pathology-Tumor Biology, Wake Forest University Health Sciences, Winston-Salem, North Carolina

Correspondence: For correspondence contact: Purnima Dubey, Medical Center Blvd., Wake Forest University Health Sciences, Winston-Salem, NC 27157-1092. E-mail: pdubey{at}wfubmc.edu

Cell-mediated therapy (immunotherapy) for the treatment of cancer is an active area of investigation in animal models and clinical trials. Despite many advances, objective responses to immunotherapy are observed in a small number of cases, for certain tumor types. To better understand differences in outcomes, it is critical to develop assays for tracking effector cell localization and function in situ. The fairly recent use of molecular imaging techniques to track cell populations has presented researchers and clinicians with a powerful diagnostic tool for determining the efficacy of cell-mediated therapy for the treatment of cancer. This review highlights the application of whole-body noninvasive radioisotopic, magnetic, and optical imaging methods for monitoring effector cells in vivo. Issues that affect sensitivity of detection, such as methods of cell marking, efficiency of cell labeling, toxicity, and limits of detection of imaging modalities, are discussed.

Key Words: cancer • imaging • cell-mediated therapy • noninvasive imaging

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.






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Copyright © 2008 by the Society of Nuclear Medicine.