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First published online August 14, 2008, 10.2967/jnumed.108.053009
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Journal of Nuclear Medicine Vol. 49 No. 9 1401-1404
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.053009

Focus on Molecular Imaging

Accelerating the Development of Novel Molecular Imaging Probes: A Role for High-Throughput Screening

H. Charles Manning, Adam Lander, Eliot McKinley and Nathan J. Mutic

Vanderbilt University Medical Center
Nashville, Tennessee

Correspondence: For correspondence contact: H. Charles Manning, Vanderbilt University Institute of Imaging Science (VUIIS), AA-1105 Medical Center North, 1161 21st Ave. South, Nashville, TN 37232-2310. E-mail: henry.c.manning{at}vanderbilt.edu

ABSTRACT

Molecular imaging is a rapidly emerging research tool and clinical discipline aimed at noninvasive, quantitative visualization of in vivo molecular processes occurring at cellular and subcellular levels. At present, advancement of the molecular imaging field is driven by the development of improved imaging hardware for use in preclinical and clinical settings, the identification and validation of new, biologically relevant imaging targets, and the development of improved imaging probes derived from novel chemistries. Of these 3 essential facets, which comprise a majority of current molecular imaging research, hardware development and novel target discovery significantly outpace the development and clinical advancement of new molecular imaging probes, particularly with respect to cancer imaging.

Key Words: molecular imaging • imaging probe discovery • HTS

FOOTNOTES

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


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