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Continuing Education |
1 Department of Nuclear Medicine, Technische Universität München, München, Germany; and 2 Department of Radiology, Technische Universität München, München, Germany
Correspondence: For correspondence or reprints contact: Andreas K. Buck, Department of Nuclear Medicine, Technische Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany. E-mail: andreas.buck{at}tum.de
In view of the commercial success of integrated PET/CT scanners, there is an increasing interest in comparable SPECT/CT systems. SPECT in combination with CT enables a direct correlation of anatomic information and functional information, resulting in better localization and definition of scintigraphic findings. Besides anatomic referencing, the added value of CT coregistration is based on the attenuation correction capabilities of CT. The number of clinical studies is limited, but pilot studies have indicated a higher specificity and a significant reduction in indeterminate findings. The superiority of SPECT/CT over planar imaging or SPECT has been demonstrated in bone scintigraphy, somatostatin receptor scintigraphy, parathyroid scintigraphy, and adrenal gland scintigraphy. Also, rates of detection of sentinel nodes by biopsy can be increased with SPECT/CT. This review highlights recent technical developments in integrated SPECT/CT systems and summarizes the current literature on potential clinical uses and future directions for SPECT/CT in cardiac, neurologic, and oncologic applications.
Key Words: scintigraphy • SPECT • CT • PET • hybrid imaging
* NOTE: FOR CE CREDIT, YOU CAN ACCESS THIS ACTIVITY THROUGH THE SNM WEB SITE (http://www.snm.org/ce_online) THROUGH AUGUST 2009.
No potential conflict of interest relevant to this article was reported.
COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.
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