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First published online July 16, 2008, 10.2967/jnumed.108.053132
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Journal of Nuclear Medicine Vol. 49 No. 8 1299-1304
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.053132

Brief Communication

Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer 99mTc-N-DBODC

Corrado Cittanti1, Licia Uccelli1, Micol Pasquali1, Alessandra Boschi1, Claudia Flammia1, Elisa Bagatin1, Massimiliano Casali1, Michael G. Stabin2, Luciano Feggi3, Melchiore Giganti1 and Adriano Duatti1

1 Laboratory of Nuclear Medicine and Nuclear Medicine Section, Department of Radiological Sciences, University of Ferrara, Ferrara, Italy; 2 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee; and 3 Nuclear Medicine Unit, Department of Diagnostic Imaging and Laboratory Medicine, S. Anna University Hospital, Ferrara, Italy

Correspondence: For correspondence or reprints contact: Adriano Duatti, Laboratory of Nuclear Medicine, Department of Radiological Sciences, University of Ferrara, Via L. Borsari, 46, 44100 Ferrara, Italy. E-mail: dta{at}unife.it

Our purpose was to evaluate the safety profile and biodistribution behavior in healthy human volunteers of the new myocardial perfusion tracer bis[(dimethoxypropylphosphanyl)ethyl]ethoxyethylamine N,N'-bis(ethoxyethyl)dithiocarbamato nitrido technetium(V) (99mTc-N-DBODC). Methods: Ten healthy male volunteers were injected with 99mTc-N-DBODC under both stress and rest conditions. Anterior and posterior planar {gamma}-camera images were collected at 5, 30, 60, 240, and 1,440 min after injection, with organ uptake quantified by region-of-interest analysis. Tracer kinetics in body fluids were determined by collecting blood and urine samples at different time points. Results: After injection, 99mTc-N-DBODC showed significant accumulation in the myocardium and prolonged retention. Under rest conditions, uptake in the heart, lungs, and liver at 5 min after injection was 1.67% ± 0.13%, 1.16% ± 0.07%, and 10.85% ± 1.72%, respectively, of administered activity. Under stress conditions, heart uptake was significantly higher (2.07% ± 0.22%). Radioactivity in the liver decreased to 3.64% ± 0.98% and 2.37% ± 0.48% at 60 and 240 min, respectively, after injection. This rapid liver clearance led to favorable heart-to-liver ratios, reaching values of 0.74 ± 0.13 at rest and 1.26 ± 0.28 during exercise 60 min after tracer administration. Radiation dose estimates were comparable to those obtained with other myocardial perfusion cationic compounds. Conclusion: The high uptake in the myocardium and the fast liver washout of 99mTc-N-DBODC will allow SPECT images of the left ventricle to be acquired early and with excellent quality.

Key Words: cardiac perfusion imaging • monocationic complexes • nitrido complexes • 99mTc

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


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