JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online July 16, 2008, 10.2967/jnumed.107.049296
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jnumed.107.049296v1
49/8/1223    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kawano, T.
Right arrow Articles by Inoue, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kawano, T.
Right arrow Articles by Inoue, T.
Journal of Nuclear Medicine Vol. 49 No. 8 1223-1231
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.107.049296

Clinical Investigation

Deep-Inspiration Breath-Hold PET/CT of Lung Cancer: Maximum Standardized Uptake Value Analysis of 108 Patients

Tsuyoshi Kawano1, Eiji Ohtake1 and Tomio Inoue2

1 Division of Nuclear Medicine, Kanagawa Cancer Center, Yokohama, Japan; and 2 Department of Radiology, Yokohama City University School of Medicine, Yokohama, Japan

Correspondence: For correspondence or reprints contact: Tsuyoshi Kawano, Division of Nuclear Medicine, Kanagawa Cancer Center Nakao 1-1-2, Asahi-ku, Yokohama, 241-0815, Japan. E-mail: kawanotsuyoshi{at}hotmail.com

Our aim was to compare the maximum standardized uptake value (SUVmax) between breath-hold (BH) PET/CT and free-breathing (FB) PET/CT. Methods: The features of phantom data were analyzed, after which a clinical study was performed. A total of 108 consecutive patients with lung cancer were examined using lutetium oxyorthosilicate (LSO)–based PET/CT. The patients were instructed to breathe freely during FB PET/CT. In BH PET/CT, the patients were instructed to hold their breath in the maximal inspiration position during the scout scan, for 10 s of the CT scan, and for as long as possible during the PET scan. BH time was recorded using a respiratory monitoring device. The %BH-index was defined as the percentage difference between SUVmax of FB PET and that of BH PET. Statistical analyses were performed using the following factors: %BH-index, age, body mass index, 18F-FDG dosage, blood glucose, BH time, lesion size, and location. Results: The highest %BH-index was 223.2. %BH-index in the lower lung area was significantly higher than that in the upper lung area (51.8 ± 49.5 vs. 16.9 ± 25.6, respectively). Lesion volume and maximum diameter in the high–%BH-index group were significantly lower than those in the low–%BH-index group, with the use of a %BH-index cutoff value of 37.l. Conclusion: SUVmax of FB PET should not be taken as accurate, especially in the lower lung area and for small pulmonary lesions. BH PET/CT is expected to enable precise measurement of SUVmax and is thus recommended as part of the standard protocol for lung cancer.

Key Words: deep-inspiration breath-hold • PET/CT • maximum SUV • lutetium oxyorthosilicate • lung cancer

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


Related articles in JNM:

This Month in JNM

JNM 2008 49: 11A-12A. [Full Text]  





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2008 by the Society of Nuclear Medicine.