JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online June 13, 2008, 10.2967/jnumed.108.050997
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jnumed.108.050997v1
49/7/1075    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Suzuki, Y.
Right arrow Articles by Berman, D. S.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suzuki, Y.
Right arrow Articles by Berman, D. S.
Journal of Nuclear Medicine Vol. 49 No. 7 1075-1079
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.050997

Clinical Investigation

Motion-Frozen Myocardial Perfusion SPECT Improves Detection of Coronary Artery Disease in Obese Patients

Yasuyuki Suzuki1, Piotr J. Slomka1,2, Arik Wolak1, Muneo Ohba1, Shoji Suzuki1, Ling De Yang1, Guido Germano1,2 and Daniel S. Berman1,2

1 Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, California; and 2 Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California

Correspondence: For correspondence or reprints contact: Piotr Slomka, Department of Imaging, Cedars-Sinai Medical Center, #A047 8700 Beverly Blvd., Los Angeles, CA 90048. E-mail: piotr.slomka{at}cshs.org

In this study, we compared the diagnostic performance of the standard SPECT with motion-frozen (MF) myocardial perfusion SPECT (MPS) in obese patients. Methods: A total of 90 consecutive obese patients (body mass index, 30.1–46.8, average, 34.3 ± 3.6; age, 63 ± 12 y; 30% women) underwent standard supine rest 201Tl/stress 99mTc dual-isotope gated MPS and cardiac catheterization within 3 mo. MF images were obtained by nonlinear warping of cardiac phases to the end-diastolic position. Total perfusion deficit (TPD) was obtained for summed (S-TPD) and motion-frozen (MF-TPD) datasets with sex-specific standard and MF normal limits. Results: The area under the receiver-operating-characteristic (ROC) curve for detection of coronary artery disease (CAD) by MF-TPD was significantly larger than that for S-TPD (0.93 ± 0.25 vs. 0.88 ± 0.32, P < 0.05). MF-TPD had higher specificity (77% vs. 55%, P < 0.05) and accuracy (89% vs. 80%, P < 0.05) than did S-TPD. Conclusion: MF processing of MPS improves CAD detection in obese patients.

Key Words: gated SPECT • myocardial perfusion • image registration • image warping • coronary artery disease • motion correction

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


Related articles in JNM:

This Month in JNM

JNM 2008 49: 13A-14A. [Full Text]  





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2008 by the Society of Nuclear Medicine.