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Nuclear Cardiac Stress Testing in the Era of Molecular Medicine^*

Correspondence: For correspondence or reprints contact: Vasken Dilsizian, MD, Division of Nuclear Medicine, Department of Diagnostic Radiology, University of Maryland Hospital and School of Medicine, 22 S. Greene St., Gudelsky Building, Room N2W78, Baltimore, MD 21201-1595. E-mail: vdilsizian{at}umm.edu

The objective of cardiac stress testing is to detect coronary artery disease (CAD) and to prevent future adverse events, such as myocardial infarction or death. The progression from electrocardiographically based stress testing to current SPECT and PET technologies has brought improvements in diagnostic efficacy and resolution. Myocardial perfusion imaging facilitates management of CAD in elective and acute settings by providing valuable diagnostic and prognostic information. Hybrid PET/CT and SPECT/CT systems impart complementary information of coronary anatomy and its physiologic significance on blood flow reserve. In the current era, diagnosis and treatment of cardiovascular disease is increasingly defined by underlying molecular and genomic aberrations rather than by clinical signs and symptoms alone. Nuclear imaging is uniquely primed to exploit the targeting of expressed cell-surface molecules and intracellular processes of cardiovascular disease and to foster the development of innovative therapeutic interventions in the future.

^* NOTE: FOR CE CREDIT, YOU CAN ACCESS THIS ACTIVITY THROUGH THE SNM WEB SITE (http://www.snm.org/ce_online) THROUGH MARCH 2009.

Dr. Dilsizian reports having an investment interest with GE Healthcare and Molecular Insight Pharma. No other potential conflict of interest relevant to this article was reported. Drs. Dilsizian and Vesely discuss investigational devices/drugs not yet approved by the FDA.

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.

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