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Planning of ¹³¹I Therapy for Graves Disease Based on the Radiation Dose to Thyroid Follicular Cells

Davor Eterovi^1,2, eljko Antunovi³, Vinko Markovi¹ and Darko Groev⁴

¹ Department of Nuclear Medicine, University Hospital Split, University of Split Medical Faculty, Split, Croatia; ² Department of Medical Physics, University Hospital Split, University of Split Medical Faculty, Split, Croatia; ³ Department of Physics, Faculty of Mathematics and Natural Sciences, University of Split, Split, Croatia; and ⁴ Clinical Department of Nuclear Medicine and Radiation Protection, Clinical Hospital Center Zagreb, Zagreb, Croatia

Correspondence: For correspondence or reprints contact: Davor Eterovi, Department of Medical Physics, Medical Faculty Split, oltanska 2, 21000 Split, Croatia. E-mail: eterovic{at}bsb.mefst.hr

We evaluated the effects on the absorbed dose to thyroid follicular cells of self-absorption of ¹³¹I radiation (specifically, β-rays) in the follicular colloid. Methods: Thyroid follicles were modeled as colloid-filled spheres, containing a uniform concentration of ¹³¹I and surrounded by a concentric monolayer of cells. Assuming close packing of identical follicles, we used Monte Carlo simulation to assess the absorbed dose to follicular cells. Results: Because of β-ray self-absorption in colloidal spheres with radii larger than 50 µm, the absorbed dose to follicular cells is less than the average thyroid absorbed dose. Conclusion: For the same thyroid mass, radioiodine thyroid uptake, and effective half-life, patients with follicles with colloidal sphere radii of 100, 200, 300, and 400 µm should be administered 9%, 15%, 21%, and 30% more ¹³¹I, respectively, than patients with colloidal sphere radii of less than 50 µm, to yield the same absorbed dose to follicular cells.

Key Words: Monte Carlo • diffuse toxic goiter • absorbed dose • echogenicity • thyroid follicle

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.

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				D. Eterovic, V. Markovic, A. Punda, and Z. Antunovic 131I Radiation Dose Distribution in Metastases of Thyroid Carcinoma J. Nucl. Med., May 1, 2009; 50(5): 833 - 834. [Full Text] [PDF]