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Spatial Heterogeneity in Sarcoma ¹⁸F-FDG Uptake as a Predictor of Patient Outcome

¹ Division of Nuclear Medicine, Departments of Radiology and Orthopedic Surgery, University of Washington, Seattle, Washington; and ² Department of Statistics, University College Cork, Cork, Ireland

Correspondence: For correspondence or reprints contact: Janet F. Eary, University of Washington, University of Washington Medical Center, 1959 NE Pacific St., Room NW041, Box 356004, Seattle, WA 98195-6004. E-mail: jeary{at}u.washington.edu

¹⁸F-FDG PET images of tumors often display highly heterogeneous spatial distribution of ¹⁸F-FDG–positive pixels. We proposed that this heterogeneity in ¹⁸F-FDG spatial distribution can be used to predict tumor biologic aggressiveness. This study presents data to support the hypothesis that a new heterogeneity-analysis algorithm applied to ¹⁸F-FDG PET images of tumors in patients is predictive of patient outcome. Methods: ¹⁸F-FDG PET images from 238 patients with sarcoma were analyzed using a new algorithm for heterogeneity analysis in tumor ¹⁸F-FDG spatial distribution. Patient characteristics, tumor histology, and patient outcome were compared with image analysis results using univariate and multivariate analysis. Cox proportional hazards models were used to further analyze the significance of the data associations. Results: Statistical analyses show that heterogeneity analysis is a strong independent predictor of patient outcome. Conclusion: The new ¹⁸F-FDG PET tumor image heterogeneity analysis method is validated for the ability to predict patient outcome in a clinical population of patients with sarcoma. This method can be extended to other PET image datasets in which heterogeneity in tissue uptake of a radiotracer may predict patient outcome.

Key Words: ¹⁸F-FDG • PET • sarcoma • image analysis

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.

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