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First published online October 16, 2008, 10.2967/jnumed.108.053264
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Journal of Nuclear Medicine Vol. 49 No. 11 1798-1803
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.053264

Brief Communication

Clinical Correlate of Brain SPECT Perfusion Abnormalities in Fibromyalgia

Eric Guedj1, Serge Cammilleri1, Jean Niboyet2, Patricia Dupont2, Eric Vidal2, Jean-Pierre Dropinski2 and Olivier Mundler1

1 Service Central de Biophysique et de Médecine Nucléaire, AP-HM Timone, Marseille, France; and 2 Unité d'Etude et de Traitement de la Douleur, Clinique La Phocéanne, Marseille, France

Correspondence: For correspondence or reprints contact: Eric Guedj, Service Central de Biophysique et de Médecine Nucléaire, Assistance Publique des Hôpitaux de Marseille, Centre Hospitalo-Universitaire de la Timone, 264 Rue Saint Pierre, 13385 Marseille Cedex 5, France. E-mail: eric.guedj{at}ap-hm.fr

The purpose of this study was to investigate the specific clinical correlate of brain SPECT perfusion abnormalities reported in fibromyalgia. Methods: We performed a whole-brain voxel-based correlation analysis involving regional cerebral blood flow and various parameters related to pain (Visual Analog Scale, Tubingen Pain Behavior Scale, and Questionnaire Douleur de Saint-Antoine Scale), disability (Fibromyalgia Impact Questionnaire [FIQ]), and anxiety and depression status (Hospital Anxiety and Depression scale) in 20 patients with fibromyalgia (P voxel < 0.005). Ten healthy control women were also included, in order to determine areas of significant hypo- and hyperperfusions in patients. Results: FIQ total score was positively correlated with bilateral parietal perfusion, including postcentral cortex. These clusters of correlation were included in the areas of significant hyperperfusion. FIQ total score was also negatively correlated with perfusion of a left anterior temporal cluster, included in the areas of significant hypoperfusions. No other clinical correlation was observed with regional cerebral blood flow. Conclusion: These results show that brain perfusion abnormalities in patients with fibromyalgia are correlated with the clinical severity of the disease.

Key Words: brain SPECT • voxel-based analysis • fibromyalgia • pain • disability

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


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