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First published online September 15, 2008, 10.2967/jnumed.108.053462
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Journal of Nuclear Medicine Vol. 49 No. 10 1601-1605
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.053462

Clinical Investigation

High 18F-FDG Uptake in Synthetic Aortic Vascular Grafts on PET/CT in Symptomatic and Asymptomatic Patients

Johan Wassélius1,2, Jonas Malmstedt1,3, Bo Kalin1,2, Stig Larsson4,5, Anders Sundin1,2, Ulf Hedin1,3 and Hans Jacobsson1,2

1 Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden; 2 Department of Radiology, Karolinska University Hospital, Stockholm, Sweden; 3 Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden; 4 Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden; and 5 Department of Hospital Physics, Karolinska University Hospital, Stockholm, Sweden

Correspondence: For correspondence or reprints contact: Johan Wassélius, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden 17176. E-mail: johan.wasselius{at}karolinska.se

Graft infection is a serious complication to vascular surgery. The aim of this study was to assess 18F-FDG uptake in vascular grafts in patients with or without symptoms of graft infection. Methods: In all 2,045 patients examined by PET/CT at our clinic, 16 patients with synthetic aortic grafts were identified and reevaluated for 18F-FDG accumulation. Clinical and biochemical data were obtained from patient records. Results: High 18F-FDG uptake was found in 10 of 12 grafts in the patients who underwent open surgery and in 1 of 4 grafts in patients who underwent endovascular aneurysm repair. On the basis of biochemical and clinical data, it was concluded that 1 of the 16 patients had a graft infection at the time of investigation. Conclusion: 18F-FDG uptake in vascular grafts was found in the vast majority of patients without graft infection. The risk of a false-positive diagnosis of graft infection by 18F-FDG PET/CT is evident.

Key Words: graft infection • imaging • nuclear medicine • 18F-FDG PET/CT • vascular surgery

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


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