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First published online December 12, 2007, 10.2967/jnumed.107.045799
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Journal of Nuclear Medicine Vol. 49 No. 1 1-4
© 2008 by Society of Nuclear Medicine
doi: 10.2967/jnumed.107.045799

Focus on Molecular Imaging

Optical Imaging: Current Applications and Future Directions

Gary D. Luker and Kathryn E. Luker

University of Michigan
Ann Arbor, Michigan

Correspondence: For correspondence contact: Gary D. Luker, MD, University of Michigan, 109 Zina Pitcher Pl., A526 BSRB, Ann Arbor, MI 48109-2200. E-mail: gluker{at}umich.edu

ABSTRACT

Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful new modalities for molecular imaging in disease and therapy. Combining innovative molecular biology and chemistry, researchers have developed optical methods for imaging a variety of cellular and molecular processes in vivo, including protein interactions, protein degradation, and protease activity. Whereas optical imaging has been used primarily for research in small-animal models, there are several areas in which optical molecular imaging will translate to clinical medicine. In this review, we summarize recent advances in optical techniques for molecular imaging and the potential impact for clinical medicine.

Key Words: bioluminescence imaging • fluorescence imaging • optical imaging probes

FOOTNOTES

COPYRIGHT © 2008 by the Society of Nuclear Medicine, Inc.


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