HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: jnumed.107.042143v1 48/10/1641    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Inui, Y. Articles by Katada, K. Search for Related Content PubMed PubMed Citation Articles by Inui, Y. Articles by Katada, K.

Evaluation of Probable or Possible Dementia with Lewy Bodies Using ¹²³I-IMP Brain Perfusion SPECT, ¹²³I-MIBG, and ^99mTc-MIBI Myocardial SPECT

¹ Department of Radiology, Fujita Health University, Toyoake, Japan; ² Department of Psychiatry, Fujita Health University, Toyoake, Japan; ³ Department of Cardiology, Fujita Health University, Toyoake, Japan; and ⁴ St. Marianna Medical Institute, Kawasaki, Japan

Correspondence: For correspondence or reprints contact: Yoshitaka Inui, MD, Department of Radiology, Fujita Health University, School of Medicine, 1-98, Dengakugakubo, Kutsukake, Toyoake, Aichi, Japan, 470-1192. E-mail: yositaka{at}fujita-hu.ac.jp

We evaluated the diagnostic usefulness of combination studies with a statistical mapping method in N-isopropyl-p-¹²³I-iodoamphetamine (¹²³I-IMP) brain perfusion SPECT, cardiac sympathetic nerve function by ¹²³I-metaiodobenzylguanidine (¹²³I-MIBG), and myocardial function by electrocardiographically gated ^99mTc-sestamibi (^99mTc-MIBI) SPECT for patients with probable or possible dementia with Lewy bodies (DLB). Methods: Twelve patients with probable DLB (7 male, 5 female; mean age ± SD, 72.3 ± 5.63 y; range, 65–82 y) and 9 patients with possible DLB (3 male, 6 female; mean age ± SD, 73.1 ± 9.23 y; range, 59–88 y) were enrolled in this study. ¹²³I-IMP SPECT images were analyzed with 3-dimensional stereotactic surface projections (3D-SSP) and the severity of ischemia was classified objectively using quantitatively analytic and display software; stereotactic extraction estimation (SEE) methods were compared with a normal database. In addition, we evaluated ¹²³I-MIBG heart-to-mediastinum (H/M) uptake ratios. Moreover, we performed ^99mTc-MIBI SPECT to evaluate myocardial perfusion and the left ventricular ejection fraction (LVEF) compared with a normal database. Results: 3D-SSP images of group comparison with healthy control subjects showed significantly decreased perfusion in the parietotemporal, occipital cortex, posterior cingulated, and precuneus regions in the probable DLB group but no significant reduction in the possible DLB group. Mean H/M ratios in the probable DLB group were significantly lower than those of the possible DLB group and the control group, respectively. Ten of 12 patients (83.3%) with probable DLB and 1 of 9 patients (11.1%) with possible DLB showed severe reduction in the bilateral occipital lobe and also a low ¹²³I-MIBG uptake. One patient (8.3%) with probable DLB and 2 patients (22.2%) with possible DLB showed no bilateral occipital hypoperfusion but showed low ¹²³I-MIBG uptake. One patient (8.3%) with probable DLB and 6 patients (66.7%) with possible DLB showed no occipital hypoperfusion and normal ¹²³I-MIBG uptake. ^99mTc-MIBI gated SPECT did not indicate any wall motion abnormality in any subjects. Conclusion: These results suggest that combined examination of cerebral blood flow with 3D-SSP and SEE analysis, and cardiac sympathetic nerve function with ¹²³I-MIBG, would be a useful supporting diagnostic method in patients with DLB—particularly, in possible DLB and when cerebral blood flow does not indicate occipital hypoperfusion.

Key Words: dementia with Lewy bodies • 3-dimensional stereotactic surface projection • ¹²³I-MIBG • ^99mTc-MIBI • gated SPECT

COPYRIGHT © 2007 by the Society of Nuclear Medicine, Inc.

Related articles in JNM:

This Month in JNM

JNM 2007 48: 11A-12A. [Full Text]