HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chareonthaitawee, P. Articles by Gibbons, R. J. Search for Related Content PubMed PubMed Citation Articles by Chareonthaitawee, P. Articles by Gibbons, R. J.

Reproducibility of Measurements of Regional Myocardial Blood Flow in a Model of Coronary Artery Disease: Comparison of H₂¹⁵O and ¹³NH₃ PET Techniques

¹ Division of Cardiovascular Diseases, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota; ² Department of Physiology and Biomedical Engineering, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota; ³ Division of Nuclear Medicine, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota; and ⁴ Division of Biostatistics, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota

Correspondence: For correspondence or reprints contact: Panithaya Chareonthaitawee, MD, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. E-mail: chareonthaitawee.panithaya{at}mayo.edu

PET absolute myocardial blood flow (MBF) with H₂¹⁵O and ¹³NH₃ are widely used in clinical and research settings. However, their reproducibility with a 16-myocardial segment model has not been examined in chronic coronary artery disease (CAD). We examined the short-term reproducibility of PET H₂¹⁵O MBF and PET ¹³NH₃ MBF in an animal model of chronic CAD. Methods: Twelve swine (mean weight ± SD, 38 ± 5 kg) underwent percutaneous placement of a copper stent in the mid circumflex coronary artery, resulting in an intense inflammatory fibrotic reaction with luminal stenosis at 4 wk. Each animal underwent repeated resting MBF measurements by PET H₂¹⁵O and PET ¹³NH₃. Attenuation-corrected images were analyzed using commercial software to yield absolute MBF (mL/min/g) in 16 myocardial segments. MBF was also normalized to the rate·pressure product (RPP). Results: By Bland–Altman reproducibility plots, the mean difference was 0.01 ± 0.18 mL/min/g and 0.01 ± 0.11 mL/min/g, with confidence limits of ±0.36 and ±0.22 mL/min/g for uncorrected regional PET H₂¹⁵O MBF and for uncorrected regional PET ¹³NH₃ MBF, respectively. The repeatability coefficient ranged from 0.09 to 0.43 mL/min/g for H₂¹⁵O and from 0.09 to 0.18 mL/min/g for ¹³NH₃ regional MBF. RPP correction did not improve reproducibility for either PET H₂¹⁵O or PET ¹³NH₃ MBF. The mean difference in PET H₂¹⁵O MBF was 0.03 ± 0.14 mL/min/g and 0.02 ± 0.19 mL/min/g for infarcted and remote regions, respectively, and in PET ¹³NH₃ MBF was 0.03 ± 0.11 mL/min/g and 0.00 ± 0.09 mL/min/g for infarcted and remote regions, respectively. Conclusion: PET H₂¹⁵O and PET ¹³NH₃ resting MBF showed excellent reproducibility in a closed-chest animal model of chronic CAD. Resting PET ¹³NH₃ MBF was more reproducible than resting PET H₂¹⁵O MBF. A high level of reproducibility was maintained in areas of lower flow with infarction for both isotopes.

Key Words: blood flow • coronary disease • imaging • radioisotopes • PET

Related articles in JNM:

This Month in JNM

JNM 2006 47: 11a-12a. [Full Text]  

This article has been cited by other articles:

				H. Fonge, K. Vunckx, H. Wang, Y. Feng, L. Mortelmans, J. Nuyts, G. Bormans, A. Verbruggen, and Y. Ni Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin {micro}SPECT Eur. Heart J., January 2, 2008; 29(2): 260 - 269. [Abstract] [Full Text] [PDF]