HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jacene, H. A. Articles by Wahl, R. L. Search for Related Content PubMed PubMed Citation Articles by Jacene, H. A. Articles by Wahl, R. L.

Effects of Pegfilgrastim on Normal Biodistribution of ¹⁸F-FDG: Preclinical and Clinical Studies

¹ Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland; and ² Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland

Correspondence: For correspondence or reprints contact: Richard L. Wahl, MD, PhD, 601 N. Caroline St., Room 3223, Baltimore, MD 21287. E-mail: rwahl{at}jhmi.edu

The purpose of this study was to evaluate the effects of pegfilgrastim, a long-acting granulocyte colony-stimulating factor, on the normal biodistribution of ¹⁸F-FDG in an animal model and in humans. Methods: Two groups of 12 rats received a single subcutaneous injection of either normal saline or pegfilgrastim. One, 7, 14, and 21 d after injection, biodistribution studies were performed 1 h after ¹⁸F-FDG injection. Sixteen breast cancer patients underwent baseline ¹⁸F-FDG PET/CT and, approximately 1 wk after receiving 1 dose of docetaxel and adjunctive pegfilgrastim, follow-up ¹⁸F-FDG PET/CT (scan 2). Standardized uptake values corrected for lean body mass (SUL) were determined for several normal organs before and after therapy. Results: In rats, bone marrow ¹⁸F-FDG uptake (standardized uptake value) was higher in the pegfilgrastim group 1 d after injection (mean ± SD, 8.3 ± 4.1 vs. 2.5 ± 0.2, P < 0.05), whereas ¹⁸F-FDG uptake in blood was lower (0.41 ± 0.06 vs. 0.49 ± 0.01, P < 0.05). In patients, mean SUL was higher in bone marrow (4.49 ± 1.50 vs. 1.33 ± 0.22, P < 0.0001), spleen (3.29 ± 0.83 vs. 1.23 ± 0.23, P < 0.0001), and liver (1.45 ± 0.25 vs. 1.31 ± 0.23, P = 0.01) but lower in brain (4.18 ± 0.76 vs. 5.14 ± 1.44, P < 0.01) on scan 2 than on the baseline scan. Conclusion: In both the animal model and humans, pegfilgrastim markedly increased bone marrow uptake of ¹⁸F-FDG and reduced ¹⁸F-FDG uptake in some normal tissues. These profound alterations in ¹⁸F-FDG biodistribution induced by pegfilgrastim must be considered when one is evaluating quantitative ¹⁸F-FDG PET scans for tumor response to therapy.

Key Words: ¹⁸F-FDG • G-CSF • pegfilgrastim • bone marrow • positron

This article has been cited by other articles:

				S. E. Sharp, B. L. Shulkin, M. J. Gelfand, S. Salisbury, and W. L. Furman 123I-MIBG Scintigraphy and 18F-FDG PET in Neuroblastoma J. Nucl. Med., August 1, 2009; 50(8): 1237 - 1243. [Abstract] [Full Text] [PDF]

				R. K. Doot, L. K. Dunnwald, E. K. Schubert, M. Muzi, L. M. Peterson, P. E. Kinahan, B. F. Kurland, and D. A. Mankoff Dynamic and Static Approaches to Quantifying 18F-FDG Uptake for Measuring Cancer Response to Therapy, Including the Effect of Granulocyte CSF J. Nucl. Med., June 1, 2007; 48(6): 920 - 925. [Abstract] [Full Text] [PDF]