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Basic Science Investigation |
1 Department of Biomedical Engineering, University of California, Davis, California; 2 Department of Radiology, Eberhard-Karls-University, Tuebingen, Germany; 3 Nuclear Magnetic Resonance Facility, University of California, Davis, California; 4 Biomedical Engineering Graduate Group, University of California, Davis, California; 5 Department of Dermatology, Eberhard-Karls-University, Tuebingen, Germany; and 6 Siemens Preclinical Solutions, Knoxville, Tennessee
Correspondence: For correspondence or reprints contact: Bernd J. Pichler, PhD, Laboratory for Preclinical Imaging and Imaging Technology, Department of Radiology, University of Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany. E-mail: Bernd.Pichler{at}med.uni-tuebingen.de
PET combined with CT has proven to be a valuable multimodality imaging device revealing both functional and anatomic information. Although PET/CT has become completely integrated into routine clinical application and also has been used in small-animal imaging, CT provides only limited soft-tissue contrast and, in preclinical studies, exposes the animal to a relatively high radiation dose. Unlike CT, MRI provides good soft-tissue contrast even without application of contrast agents and, furthermore, does not require ionizing radiation. Methods: This project focused on combining a high-resolution PET scanner with a 7-T MRI system for animal research. Because classic PET detectors based on photomultiplier tubes cannot be used in high magnetic fields, we used a detector technology based on 10 x 10 lutetium oxyorthosilicate crystal arrays and 3 x 3 avalanche photodiode arrays. A ring of such PET detectors will ultimately be used as an insert for the 119-mm-diameter MRI bore. Results: Initial measurements with 1 PET detector module in the 7-T field during application of MRI sequences were encouraging. Position profiles from the PET detectors and a first MR image of a mouse could be acquired simultaneously. Conclusion: Further work will concentrate on the construction of a full PET detector ring with compact, integrated electronics.
Key Words: instrumentation • molecular imaging • PET • animal imaging • multimodality imaging • PET/MRI development
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