HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Slifstein, M. Articles by Laruelle, M. Search for Related Content PubMed PubMed Citation Articles by Slifstein, M. Articles by Laruelle, M.

Biodistribution and Radiation Dosimetry of the Dopamine D₂ Ligand ¹¹C-Raclopride Determined from Human Whole-Body PET

¹ Department of Psychiatry, Columbia University, New York, New York; ² Division of Functional Brain Mapping, New York State Psychiatric Institute, New York, New York; and ³ Department of Radiology, Columbia University, New York, New York

Correspondence: For correspondence or reprints contact: Mark Slifstein, PhD, 1051 Riverside Dr., Unit 31, New York, NY, 10032. E-mail: mms218{at}columbia.edu

Whole-body radiation dosimetry of ¹¹C-raclopride was performed in healthy human volunteers. Methods: Subjects (n = 6) were scanned with PET. Subjects received single-bolus injections of ¹¹C-raclopride (S-(–)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)]methyl-2-hydroxy-6-methoxybenzamide) (533 ± 104 MBq) and were scanned for approximately 110 min with a 2-dimensional whole-body protocol. Regions of interest were placed over all visually identifiable organs and time–activity curves were generated. Residence times were computed as the area under the curve of the time–activity curves, normalized to injected activities and standard values of organ volumes. Absorbed doses were computed according to the MIRD schema with MIRDOSE3.1 software. Results: Organs with the highest radiation burden were gallbladder wall, small intestine, liver, and urinary bladder wall. Conclusion: On the basis of the estimated absorbed dose, the maximum allowable single study dose under U.S. federal regulations for studies performed under Radiation Drug Research Committee is 1.58 GBq (42.8 mCi). This is still considerably higher than the doses of ¹¹C-raclopride commonly used in research PET (370–555 MBq).

Key Words: ¹¹C-raclopride • D₂ receptor • dopamine • biodistribution • radiation dosimetry • PET

Related articles in JNM:

This Month in JNM

JNM 2006 47: 7a-8a. [Full Text]  

This article has been cited by other articles:

				C. M. Laymon, N. S. Mason, W. G. Frankle, J. P. Carney, B. J. Lopresti, M. Y. Litschge, C. A. Mathis, J. M. Mountz, and R. Narendran Human Biodistribution and Dosimetry of the D2/3 Agonist 11C-N-Propylnorapomorphine (11C-NPA) Determined from PET J. Nucl. Med., May 1, 2009; 50(5): 814 - 817. [Abstract] [Full Text] [PDF]

				J. R. Virta, T. Tolvanen, K. Nagren, A. Bruck, A. Roivainen, and J. O. Rinne 1-11C-Methyl-4-Piperidinyl-N-Butyrate Radiation Dosimetry in Humans by Dynamic Organ-Specific Evaluation J. Nucl. Med., March 1, 2008; 49(3): 347 - 353. [Abstract] [Full Text] [PDF]