HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Marie, P.-Y. Articles by Bertrand, A. Search for Related Content PubMed PubMed Citation Articles by Marie, P.-Y. Articles by Bertrand, A.

OSEM Reconstruction, Associated with Temporal Fourier and Depth-Dependant Resolution Recovery Filtering, Enhances Results from Sestamibi and ²⁰¹Tl 16-Interval Gated SPECT

¹ Department of Nuclear Medicine, University Hospital, Nancy, France
² UHP-INSERM U684, Nancy, France
³ UHP-INSERM ERI13, Nancy, France
⁴ Department of Nuclear Medicine, Arizona-VUB, Brussels, Belgium

Gated SPECT recorded with 16 intervals determines left ventricular (LV) ejection fraction more accurately than does gated SPECT recorded with 8 intervals but produces higher image noise. This study aimed to assess the results from sestamibi and ²⁰¹Tl 16-interval gated SPECT when both signal-to-noise ratio and spatial resolution were enhanced with an original method of reconstruction. Methods: Forty patients with coronary artery disease underwent ²⁰¹Tl and sestamibi 16-interval gated SPECT and, to be used as a reference, cardiac MRI. Assessments of global and regional LV function provided by ordered-subsets expectation maximization (OSEM) with depth-dependant resolution recovery and temporal Fourier filtering were compared with those from conventional filtered backprojection (FBP) previously optimized by screening various filter frequencies and various temporal smoothing levels. Results: For both tracers, LV ejection fraction was determined best when the association of OSEM with depth-dependant resolution recovery was used alone, with temporal Fourier filtering, or with a slight 2-frame temporal smoothing: Mean absolute values of relative errors ranged from 3.2% to 3.6% (4.0%–7.9% for FBP), and coefficient correlation ranged from 0.91 to 0.93 (0.70–0.91 for FBP). Among these 3 reconstruction methods, the association of OSEM with depth-dependant resolution recovery with temporal Fourier filtering provided the highest signal-to-noise ratio, with mean increases of 54% for sestamibi and 80% for ²⁰¹Tl when compared with FBP, and the best analysis of segmental contractility, with exact agreement rates with MRI being 73% for ²⁰¹Tl and 79% for sestamibi. Conclusion: OSEM associated with temporal Fourier filtering and depth-dependant resolution recovery filtering enhances the LV function assessment provided by sestamibi and ²⁰¹Tl 16-interval gated SPECT and dramatically reduces image noise, a property that enhances and facilitates image interpretation.

Key Words: gated SPECT • MRI • ejection fraction • sestamibi • ²⁰¹Tl

Related articles in JNM:

THIS MONTH IN JNM

JNM 2005 46: 7a-8a. [Full Text]