HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Farsad, M. Articles by Fanti, S. Search for Related Content PubMed PubMed Citation Articles by Farsad, M. Articles by Fanti, S.

Detection and Localization of Prostate Cancer: Correlation of ¹¹C-Choline PET/CT with Histopathologic Step-Section Analysis

¹ Nuclear Medicine Department, PET Unit, Policlinico S. Orsola-Malpighi, Bologna, Italy
² Urology Department, Università di Bologna, Bologna, Italy
³ Pathology Department, Università di Bologna, Bologna, Italy
⁴ Radiology Department, Università di Bologna, Bologna, Italy

This study evaluated the potential usefulness of ¹¹C-choline PET/CT for detection and localization of tumors within the prostate. We used the results of step-section histopathologic examination as the standard of reference. Methods: The results were analyzed on a sextant basis. We reviewed the results of the ¹¹C-choline PET/CT scans of 36 patients with prostate cancer and of 5 control subjects with bladder cancer. All patients underwent ¹¹C-choline PET/CT and, subsequently, radical prostatectomy with lymph node dissection within 1 mo. ¹¹C-Choline PET/CT scans were obtained 5–10 min after intravenous injection of 370–555 MBq of ¹¹C-choline. Images were reviewed visually and semiquantitatively using maximum SUV and tumor-to-background ratio. Results: On a sextant basis, histopathologic analysis detected cancer foci in 143 of 216 sextants; high-grade prostate intraepithelial neoplasm foci were detected in 89 of 216 sextants (in 59 sextants in association with carcinoma, in 30 sextants alone), acute prostatitis was detected in 7 of 216 sextants (in 3 sextants in association with carcinoma, in 4 sextants alone), and 39 of 216 sextants were normal. PET/CT demonstrated focal ¹¹C-choline uptake in 108 sextants (94 of which involved tumor), and 108 sextants showed no abnormal ¹¹C-choline uptake (49 of which were false negative). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of PET/CT were 66%, 81%, 71%, 87%, and 55%, respectively. In the 5 control subjects, high-grade prostate intraepithelial neoplasm was detected at histologic examination in 16 of 30 sextants. PET/CT showed increased ¹¹C-choline uptake in 5 of 16 sextants. Conclusion: This study demonstrated the feasibility of using ¹¹C-choline PET/CT to identify cancer foci within the prostate. However, we also found that ¹¹C-choline PET/CT has a relative high rate of false-negative results on a sextant basis and that prostatic disorders other than cancer may accumulate ¹¹C-choline. Therefore, our data do not support the routine use of PET/CT with ¹¹C-choline as a first-line screening procedure for prostate cancer in men at high risk.

Key Words: ¹¹C-choline PET/CT • prostate cancer • tumor localization • radionuclide imaging

Related articles in JNM:

THIS MONTH IN JNM

JNM 2005 46: 8a-9a. [Full Text]  

This article has been cited by other articles:

				M. Piert, H. Park, A. Khan, J. Siddiqui, H. Hussain, T. Chenevert, D. Wood, T. Johnson, R. B. Shah, and C. Meyer Detection of Aggressive Primary Prostate Cancer with 11C-Choline PET/CT Using Multimodality Fusion Techniques J. Nucl. Med., October 1, 2009; 50(10): 1585 - 1593. [Abstract] [Full Text] [PDF]

				B. Turkbey, P. S. Albert, K. Kurdziel, and P. L. Choyke Imaging Localized Prostate Cancer: Current Approaches and New Developments Am. J. Roentgenol., June 1, 2009; 192(6): 1471 - 1480. [Abstract] [Full Text] [PDF]

				C. Plathow and W. A. Weber Tumor Cell Metabolism Imaging J. Nucl. Med., June 1, 2008; 49(Suppl_2): 43S - 63S. [Abstract] [Full Text] [PDF]

				C. Testa, R. Schiavina, R. Lodi, E. Salizzoni, B. Corti, M. Farsad, J. Kurhanewicz, F. Manferrari, E. Brunocilla, C. Tonon, et al. Prostate Cancer: Sextant Localization with MR Imaging, MR Spectroscopy, and 11C-Choline PET/CT Radiology, September 1, 2007; 244(3): 797 - 806. [Abstract] [Full Text] [PDF]

				D. M. Schuster, J. R. Votaw, P. T. Nieh, W. Yu, J. A. Nye, V. Master, F. D. Bowman, M. M. Issa, and M. M. Goodman Initial Experience with the Radiotracer Anti-1-Amino-3-18F-Fluorocyclobutane-1-Carboxylic Acid with PET/CT in Prostate Carcinoma J. Nucl. Med., January 1, 2007; 48(1): 56 - 63. [Abstract] [Full Text] [PDF]

				S. N. Reske, N. M. Blumstein, B. Neumaier, H.-W. Gottfried, F. Finsterbusch, D. Kocot, P. Moller, G. Glatting, and S. Perner Imaging Prostate Cancer with 11C-Choline PET/CT J. Nucl. Med., August 1, 2006; 47(8): 1249 - 1254. [Abstract] [Full Text] [PDF]