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Journal of Nuclear Medicine Vol. 45 No. 9 1444-1449
© 2004 by Society of Nuclear Medicine


Clinical Investigations

Superimposed Display of Coronary Artery on Gated Myocardial Perfusion Scintigraphy

Yoshihiro Nishimura, MSc1,2, Kazuki Fukuchi, MD1, Tetsuro Katafuchi, PhD1, Masayoshi Sagou, BSc1, Hisashi Oka, BSc1, Yoshio Ishida, MD1 and Kenya Murase, PhD2

1 Department of Radiology, National Cardiovascular Center, Suita, Osaka, Japan
2 Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

Fusion of images of vascular anatomy and of myocardial perfusion images might be helpful for understanding the relationship between ischemia and the responsible vessels. The aim of this study was to develop a simple means of superimposing the images obtained from coronary angiography and gated myocardial perfusion SPECT. Methods: Right and left oblique views from conventional coronary angiography and left ventriculography (LVG) were stored as 512 x 512 x 8-bit digital datasets and combined. We reconstructed images from routine gated myocardial perfusion imaging (MPI) by using 99mTc-tetrofosmin to match the oblique positions between the image from MPI and combined angiographic images. We then generated a 3-dimensional (3D) surface map by using the quantitative gated SPECT (QGS)/quantitative perfusion SPECT (QPS) program. Both the combined angiographic images and the 3D surface map were rescaled and unified by registering the internal landmarks between the 2 images. After subtraction of the LVG image, the coronary angiogram and the 3D surface map were fused into 1 image. All processes were performed with the QGS/QPS program and commercially available graphic software. We applied this method to datasets from a cardiac phantom and from several patients with coronary artery disease. Results: In the phantom study, our technique could obtain a 3D surface map in which the oblique angle was identified as that of radiography and could realize image registration and superimposition of radiography on scintigraphy. The preliminary results from the patients indicated that the markedly stenotic vessels showed good coincidence with the regional myocardial perfusion abnormalities on the unified images. In addition, these images could show the relationship between the coronary artery and regional wall motion in the gated mode. Conclusion: We developed a simple method of superimposing the image of the coronary artery tree on images from gated MPI. The technique yielded useful information about myocardial perfusion and function as well as the supplying coronary artery.

Key Words: coronary angiography • myocardial perfusion • image fusion


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[Abstract] [Full Text] [PDF]




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