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Scintimammography with Dedicated Breast Camera Detects and Localizes Occult Carcinoma

¹ Department of Nuclear Medicine, Hamot Medical Center, Erie, Pennsylvania
² Loyola University, Chicago, Illinois
³ Lake Erie Research Institute, Erie, Pennsylvania

This study assessed the utility of scintimammography using a standard -camera and a dedicated breast camera as an adjuvant to mammography and clinical examination. Methods: The study population comprised 37 patients with dense breasts and a family or personal history of breast cancer. The subjects had no suggestive clinical or mammographic findings. After intravenous administration of ^99mTc-sestamibi, the patients were imaged using a conventional -camera and a dedicated breast camera that allowed breast compression during image acquisition. Images were interpreted independently by 2 reviewers. All patients with positive scintimammography findings underwent biopsy. Results: Dedicated breast camera results were positive in 13.5% (5/37) of patients. Biopsy of these 5 patients yielded 3 carcinomas: an infiltrating lobular carcinoma, a ductal carcinoma in situ, and an infiltrating tubular carcinoma. These 3 carcinomas were undetectable by clinical breast examination or mammography, even on retrospective review. Only one of these, the tubular carcinoma, was readily detectable by the standard -camera. Conclusion: Scintimammography using a dedicated breast camera may augment mammography and clinical breast examination for the subset of women who have dense breast tissue and are at high risk of breast cancer.

Key Words: scintimammography • -camera • breast cancer

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