HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bradley, J. D. Articles by Siegel, B. A. Search for Related Content PubMed PubMed Citation Articles by Bradley, J. D. Articles by Siegel, B. A.

Implementing Biologic Target Volumes in Radiation Treatment Planning for Non-Small Cell Lung Cancer

¹ Department of Radiation Oncology, Mallinckrodt Institute of Radiology, St. Louis, Missouri
² Department of Radiology, Mallinckrodt Institute of Radiology, St. Louis, Missouri
³ Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri

¹⁸F-FDG PET offers the radiation oncology community the ability to incorporate biologic information into radiation therapy targets. To date, most of the work in this arena has involved patients with non–small cell lung cancer (NSCLC). The literature suggests that biologic targeting with PET alters the radiation treatment volume significantly in 30%–60% of NSCLC patients for whom definitive therapy is planned. This is mostly the result of the incorporation of regional nodes with ¹⁸F-FDG avidity that were previously judged to be uninvolved by CT criteria. The development of the integrated PET/CT scanner is a valuable tool that improves diagnostic accuracy for staging this disease and will increase the accessibility of PET for radiation treatment planning. Its implementation into radiation treatment planning requires strong collaboration between radiation oncologists and nuclear physicians. In this report, we will review the literature on PET-based radiation treatment planning, its potential benefits, and future challenges.

Key Words: PET/CT • non–small cell lung cancer • radiation therapy

This article has been cited by other articles:

				M. K. Werner, J. A. Parker, G. M. Kolodny, J. R. English, and M. R. Palmer Respiratory Gating Enhances Imaging of Pulmonary Nodules and Measurement of Tracer Uptake in FDG PET/CT Am. J. Roentgenol., December 1, 2009; 193(6): 1640 - 1645. [Abstract] [Full Text] [PDF]

				E. C. Ford, J. Herman, E. Yorke, and R. L. Wahl 18F-FDG PET/CT for Image-Guided and Intensity-Modulated Radiotherapy J. Nucl. Med., October 1, 2009; 50(10): 1655 - 1665. [Abstract] [Full Text] [PDF]

				R. A. Bundschuh, A. Martinez-Moeller, M. Essler, M.-J. Martinez, S. G. Nekolla, S. I. Ziegler, and M. Schwaiger Postacquisition Detection of Tumor Motion in the Lung and Upper Abdomen Using List-Mode PET Data: A Feasibility Study J. Nucl. Med., May 1, 2007; 48(5): 758 - 763. [Abstract] [Full Text] [PDF]

				T. M. Blodgett, C. C. Meltzer, and D. W. Townsend PET/CT: Form and Function Radiology, February 1, 2007; 242(2): 360 - 385. [Abstract] [Full Text] [PDF]

				J. Czernin and H. R. Schelbert Introduction J. Nucl. Med., January 1, 2007; 48(1_suppl): 2S - 3S. [Full Text] [PDF]

				J. Barentsz, S. Takahashi, W. Oyen, R. Mus, P. De Mulder, R. Reznek, M. Oudkerk, and W. Mali Commonly Used Imaging Techniques for Diagnosis and Staging J. Clin. Oncol., July 10, 2006; 24(20): 3234 - 3244. [Abstract] [Full Text] [PDF]