HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tiling, R. Articles by Hahn, K. Search for Related Content PubMed PubMed Citation Articles by Tiling, R. Articles by Hahn, K.

Tissue-Specific Effects on Uptake of ^99mTc-Sestamibi by Breast Lesions: A Targeted Analysis of False Scintigraphic Diagnoses

¹ Department of Nuclear Medicine, Innenstadt Ludwig-Maximilians-University of Munich, Munich, Germany
² Department of Gynecology and Obstetrics, Innenstadt Ludwig-Maximilians-University of Munich, Munich, Germany

The limited spatial resolution of -cameras is commonly considered the main reason for the low sensitivity of scintimammography in the detection of small carcinomas. The present study assessed whether uptake of ^99mTc-sestambi is affected by certain tissue-specific parameters besides the size of the tumor. Methods: Surgical specimens from 75 patients (30 benign lesions, 8 of which had shown false-positive scintigraphic findings, and 45 carcinomas, 8 of which had shown false-negative scintigraphic findings) were subjected to a distinct histopathologic/immunohistochemical reevaluation. Tissue-specific parameters (lesion size, cellular density, vascularity, signs of inflammation, proliferative activity, multidrug resistance expression, and receptor status) were visually scored and correlated with the sestamibi uptake on scintimammograms. Results: A clear relationship was found between sestamibi uptake and tumor size. As previously assumed, a lesion size of less than 1 cm in diameter was found to be one reason for false-negative scintigraphic diagnoses. In addition, a low cell count, low vascularity, and absence of inflammation in carcinomas had a negative effect on uptake of the radiopharmaceutical. The decisive factor for increased tracer uptake by benign lesions was the presence of inflammatory changes. No correlation could be found between sestamibi uptake and proliferative cellular activity, multidrug resistance expression, or the receptor status of the tumor. Conclusion: Because all mentioned findings were statistically significant only in part, it is to be supposed that uptake of ^99mTc-sestambi by breast lesions is determined by various tissue parameters in interaction.

Key Words: scintimammography • breast cancer • ^99mTc-sestambi • histopathology

Related articles in JNM:

THIS MONTH IN JNM

JNM 2004 45: 8A-9A. [Full Text]  

This article has been cited by other articles:

				C. Wittram, S. E. Jones, and J. A. Scott 99mTc sestamibi uptake by acute pulmonary embolism. Am. J. Roentgenol., December 1, 2006; 187(6): 1611 - 1613. [Full Text] [PDF]

				O. Schillaci Is There a Clinical Role for Scintimammography in Breast Cancer Diagnosis? J. Nucl. Med., October 1, 2005; 46(10): 1571 - 1573. [Full Text] [PDF]