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Regional Cerebral Blood Flow in Patients with Mild Hypothyroidism

¹ Department of Medical Biophysics and Nuclear Medicine, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
² Department of Neurology, Agnes Ginges Center for Human Neurogenetics, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
³ Department of Psychiatry, Hadassah–Hebrew University Medical Center, Jerusalem, Israel

ABSTRACT

Emotional and cognitive abnormalities are common in adult hypothyroidism. Few studies, however, have evaluated cerebral perfusion and metabolism in this disorder. The aims of this study were to compare regional cerebral blood flow (rCBF) between hypothyroid patients and healthy subjects and assess flow during the euthyroid state after treatment. Methods: Ten mildly hypothyroid patients, before and after thyroxine treatment, and 10 healthy controls underwent ^99mTc-hexamethylpropyleneamine oxime brain SPECT, MRI, and psychometric testing. SPECT images were analyzed using statistical parametric mapping. Results: Compared with controls, rCBF in patients before treatment was lower in right parietooccipital gyri, cuneus, posterior cingulate, lingual gyrus, fusiform, insula, and pre- and postcentral gyri. Perfusion did not normalize on a return to the euthyroid state. Conclusion: Decreased rCBF in mild hypothyroidism is found in regions mediating attention, motor speed, memory, and visuospatial processing, faculties affected in hypothyroidism. Follow-up studies are needed to determine the longer-term persistence of perfusion abnormalities in this disorder.

Key Words: hypothyroidism • brain SPECT • cerebral blood flow • cognition • mood

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