HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Keidar, Z. Articles by Israel, O. Search for Related Content PubMed PubMed Citation Articles by Keidar, Z. Articles by Israel, O.

PET/CT Using ¹⁸F-FDG in Suspected Lung Cancer Recurrence: Diagnostic Value and Impact on Patient Management

¹ Department of Nuclear Medicine, Rambam Medical Center, Haifa, Israel
² School of Medicine, Technion–Israel Institute of Technology, Haifa, Israel
³ Department of Oncology, Rambam Medical Center, Haifa, Israel
⁴ Department of Diagnostic Radiology, Rambam Medical Center, Haifa, Israel
⁵ Department of Thoracic Surgery, Rambam Medical Center, Haifa, Israel

The goal of this study was to assess the value of hybrid imaging using a combined PET/CT device with ¹⁸F-FDG in the diagnosis and clinical management of suspected recurrent lung cancer. Methods: Forty-two patients with non–small cell lung cancer (NSCLC) with suspected recurrence due to new clinical, biochemical, and radiologic findings were prospectively evaluated. PET/CT results were compared with PET interpreted with side-by-side CT data. A final diagnosis of recurrence was confirmed by histologic tissue sampling during surgery or biopsy or by further clinical and radiologic work-up. The impact of PET/CT on patient management was assessed. Results: Twenty-four of 27 positive PET/CT studies (89%) were proven to have recurrent disease. Fourteen of 15 negative PET/CT studies (93%) had no evidence of disease. The sensitivity, specificity, and positive and negative predictive values of PET/CT for diagnosis of recurrence were 96%, 82%, 89%, and 93% compared with 96%, 53%, 75%, and 90%, respectively, for PET. PET/CT changed the PET lesion classification in 22 patients (52%), by determining the precise localization of sites of increased ¹⁸F-FDG uptake. PET/CT changed the management of 12 patients (29%) by eliminating previously planned diagnostic procedures (5 patients), by initiating a previously unplanned treatment option (4 patients), or by inducing a change in the planned therapeutic approach (3 patients). Conclusion: In patients with a suspected recurrence of NSCLC, PET/CT provides a better anatomic localization of suspicious lesions compared with PET interpreted with side-by-side CT data. This improved diagnostic performance of PET/CT has a further impact on the clinical management and treatment planning of the patients.

Key Words: PET/CT • non–small cell lung cancer • recurrence

Related articles in JNM:

THIS MONTH IN JNM

JNM 2004 45: 8A-9A. [Full Text]  

This article has been cited by other articles:

				Y. Nakamoto, K. Togashi, T. Kaneta, H. Fukuda, K. Nakajima, K. Kitajima, K. Murakami, H. Fujii, M. Satake, U. Tateishi, et al. Clinical Value of Whole-body FDG-PET for Recurrent Gastric Cancer: A Multicenter Study Jpn. J. Clin. Oncol., May 1, 2009; 39(5): 297 - 302. [Abstract] [Full Text] [PDF]

				J. J. Erasmus, E. Rohren, and S. G. Swisher Prognosis and Reevaluation of Lung Cancer by Positron Emission Tomography Imaging Proceedings of the ATS, April 15, 2009; 6(2): 171 - 179. [Abstract] [Full Text] [PDF]

				M. B. Dolovich and D. P. Schuster Positron Emission Tomography and Computed Tomography versus Positron Emission Tomography Computed Tomography: Tools for Imaging the Lung Proceedings of the ATS, August 1, 2007; 4(4): 328 - 333. [Abstract] [Full Text] [PDF]

				A. V. Taira, R. J. Herfkens, S. S. Gambhir, and A. Quon Detection of Bone Metastases: Assessment of Integrated FDG PET/CT Imaging Radiology, April 1, 2007; 243(1): 204 - 211. [Abstract] [Full Text] [PDF]

				O. Israel and A. Kuten Early Detection of Cancer Recurrence: 18F-FDG PET/CT Can Make a Difference in Diagnosis and Patient Care J. Nucl. Med., January 1, 2007; 48(1_suppl): 28S - 35S. [Abstract] [Full Text] [PDF]

				H. Kuehl, P. Veit, S. J. Rosenbaum, A. Bockisch, and G. Antoch Can PET/CT Replace Separate Diagnostic CT for Cancer Imaging? Optimizing CT Protocols for Imaging Cancers of the Chest and Abdomen J. Nucl. Med., January 1, 2007; 48(1_suppl): 45S - 57S. [Abstract] [Full Text] [PDF]

				J. Czernin, M. Allen-Auerbach, and H. R. Schelbert Improvements in Cancer Staging with PET/CT: Literature-Based Evidence as of September 2006 J. Nucl. Med., January 1, 2007; 48(1_suppl): 78S - 88S. [Abstract] [Full Text] [PDF]

				J. D. Berry and G. J. R. Cook Positron emission tomography in oncology Br. Med. Bull., December 14, 2006; (2006) ldl013v1. [Abstract] [Full Text] [PDF]

				M. E. Juweid and B. D. Cheson Positron-Emission Tomography and Assessment of Cancer Therapy N. Engl. J. Med., February 2, 2006; 354(5): 496 - 507. [Full Text] [PDF]

				G. K. von Schulthess, H. C. Steinert, and T. F. Hany Integrated PET/CT: Current Applications and Future Directions Radiology, February 1, 2006; 238(2): 405 - 422. [Abstract] [Full Text] [PDF]

				P J Ell The contribution of PET/CT to improved patient management Br. J. Radiol., January 1, 2006; 79(937): 32 - 36. [Abstract] [Full Text] [PDF]