HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Okazawa, H. Articles by Takahashi, M. Search for Related Content PubMed PubMed Citation Articles by Okazawa, H. Articles by Takahashi, M.

Differences in Vasodilatory Capacity and Changes in Cerebral Blood Flow Induced by Acetazolamide in Patients with Cerebrovascular Disease

¹ PET Unit, Research Institute, Shiga Medical Center, Moriyama, Japan
² Biomedical Imaging Research Center, Fukui Medical University, Fukui, Japan

To investigate changes in cerebral blood flow (CBF) and blood volume induced by acetazolamide (ACZ) in patients with a variable autoregulatory status responding to reduced perfusion pressure, PET measurements of hemodynamic parameters were performed on patients with cerebrovascular disease, and the relationships between the parameters were evaluated. Methods: Sixteen patients with unilateral major cerebral arterial occlusive disease underwent PET studies with ¹⁵O-gas and the steady-state method to obtain hemodynamic parameters in the brain. All patients and 8 healthy volunteers underwent H₂¹⁵O PET at baseline and 10 min after ACZ injection to calculate the CBF and arterial-to-capillary blood volume (V₀) based on a 2-compartment model. Results: The regional CBF (rCBF) and V₀ increased significantly after ACZ administration in volunteers and in the hemisphere contralateral to the ischemic side in patients. However, in a subgroup of patients with disease who showed a significant reduction in the rCBF increase in the ipsilateral hemisphere, the ACZ challenge caused a decrease in the rCBF even though the V₀ showed a significant increase. The reduction in the rCBF increase was associated with an asymmetric increase in oxygen extraction fraction (OEF) but not with an absolute OEF increase. Conclusion: The increases in rCBF and V₀ induced by ACZ administration, as well as absolute OEF value in the baseline condition, did not necessarily parallel each other in the ipsilateral hemispheres of patients. Thus, the increase in rCBF after ACZ challenge may not represent vasodilatory capacity in patients with cerebrovascular disease, especially in the regions with a reduced rCBF response.

Key Words: acetazolamide • cerebrovascular disease • cerebral blood flow • vasodilatory capacity • cerebral blood volume

This article has been cited by other articles:

				D. M. Mandell, J. S. Han, J. Poublanc, A. P. Crawley, J. A. Stainsby, J. A. Fisher, and D. J. Mikulis Mapping Cerebrovascular Reactivity Using Blood Oxygen Level-Dependent MRI in Patients With Arterial Steno-occlusive Disease: Comparison With Arterial Spin Labeling MRI Stroke, July 1, 2008; 39(7): 2021 - 2028. [Abstract] [Full Text] [PDF]

				S. Kuroda, T. Shiga, T. Ishikawa, K. Houkin, T. Narita, C. Katoh, N. Tamaki, and Y. Iwasaki Reduced Blood Flow and Preserved Vasoreactivity Characterize Oxygen Hypometabolism Due to Incomplete Infarction in Occlusive Carotid Artery Diseases J. Nucl. Med., June 1, 2004; 45(6): 943 - 949. [Abstract] [Full Text] [PDF]