HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bouchet, L. G. Articles by Sgouros, G. Search for Related Content PubMed PubMed Citation Articles by Bouchet, L. G. Articles by Sgouros, G.

MIRD Pamphlet No. 19: Absorbed Fractions and Radionuclide S Values for Six Age-Dependent Multiregion Models of the Kidney^*

¹ Department of Neurological Surgery, University of Florida, Gainesville, Florida
² Department of Biomedical Engineering, University of Florida, Gainesville, Florida
³ Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida
⁴ Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio
⁵ Nuclear Physics Enterprises, Cherry Hill, New Jersey
⁶ Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France
⁷ Department of Radiology, Johns Hopkins Medical Institutes, Baltimore, Maryland

As one of the major organs of the excretory pathway, the kidneys represent a frequent source of radiopharmaceutical uptake in both diagnostic and therapeutic nuclear medicine. The unique organization of the functional tissues of the organ ensures transient changes in suborgan localization of renal activity. Current single-region dosimetric models of the kidneys, however, force the assumption of a uniform distribution of radioactivity across the entire organ. The average absorbed dose to the kidneys predicted by such models can misrepresent local regional doses to specific substructures. Methods: To facilitate suborgan dosimetry for the kidneys, 6 new age-dependent multiregion kidney models are presented. The outer dimensions of the models conform to those used currently in single-region kidney models, whereas interior structures are defined for the renal cortex, the medullary pyramids with papillae (2 vertical and 3 horizontal), and the renal pelvis. Absorbed fractions of energy were calculated for both photon and electron sources (10 keV to 4 MeV) located in each source region within the 6 age-dependent models. The absorbed fractions were then used to assemble S values for radionuclides of potential interest in suborgan kidney dosimetry. Results: For the adult, the absorbed dose to the renal cortex for ⁹⁰Y-labeled compounds retained within that subregion is 1.3 times that predicted by the single-region kidney model, whereas the medullary dose is only 26% of that same single-region value. For compounds that are rapidly filtered in the kidneys, the renal cortex dose is approximately one-half of that predicted under the single-region model, whereas the tissues of the medullary pyramids receive an absorbed dose 1.5–1.8 times larger. Conclusion: The multiregion model described here permits estimates of regional kidney dose not previously supported by current single-region models. Full utilization of the new model, however, requires serial imaging of the kidneys with regions of interest assigned to the renal cortex and medulla.

Key Words: kidney dosimetry • pediatrics • suborgan dosimetry • MIRD schema

This article has been cited by other articles:

				B. W. Wessels, M. W. Konijnenberg, R. G. Dale, H. B. Breitz, M. Cremonesi, R. F. Meredith, A. J. Green, L. G. Bouchet, A. B. Brill, W. E. Bolch, et al. MIRD Pamphlet No. 20: The Effect of Model Assumptions on Kidney Dosimetry and Response--Implications for Radionuclide Therapy J. Nucl. Med., November 1, 2008; 49(11): 1884 - 1899. [Abstract] [Full Text] [PDF]

				M. Konijnenberg, M. Melis, R. Valkema, E. Krenning, and M. de Jong Radiation Dose Distribution in Human Kidneys by Octreotides in Peptide Receptor Radionuclide Therapy J. Nucl. Med., January 1, 2007; 48(1): 134 - 142. [Abstract] [Full Text] [PDF]

				R. W. Howell, P. V. S. V. Neti, M. Pinto, B. I. Gerashchenko, V. R. Narra, and E. I. Azzam Challenges and progress in predicting biological responses to incorporated radioactivity Radiat Prot Dosimetry, December 1, 2006; 122(1-4): 521 - 527. [Abstract] [Full Text] [PDF]

				M. Cremonesi, M. Ferrari, L. Bodei, G. Tosi, and G. Paganelli Dosimetry in Peptide Radionuclide Receptor Therapy: A Review J. Nucl. Med., September 1, 2006; 47(9): 1467 - 1475. [Abstract] [Full Text] [PDF]

				T. Zenz, R. F. Schlenk, G. Glatting, B. Neumaier, N. Blumstein, I. Buchmann, S. von Harsdorf, M. Ringhoffer, M. Wiesneth, F. Keller, et al. Bone Marrow Transplantation Nephropathy after an Intensified Conditioning Regimen with Radioimmunotherapy and Allogeneic Stem Cell Transplantation J. Nucl. Med., February 1, 2006; 47(2): 278 - 286. [Abstract] [Full Text] [PDF]

				H. Karacay, P.-Y. Brard, R. M. Sharkey, C.-H. Chang, E. A. Rossi, W. J. McBride, D. R. Ragland, I. D. Horak, and D. M. Goldenberg Therapeutic Advantage of Pretargeted Radioimmunotherapy Using a Recombinant Bispecific Antibody in a Human Colon Cancer Xenograft Clin. Cancer Res., November 1, 2005; 11(21): 7879 - 7885. [Abstract] [Full Text] [PDF]

				J. S. Jaggi, S. V. Seshan, M. R. McDevitt, K. LaPerle, G. Sgouros, and D. A. Scheinberg Renal Tubulointerstitial Changes after Internal Irradiation with {alpha}-Particle-Emitting Actinium Daughters J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2677 - 2689. [Abstract] [Full Text] [PDF]

				M. G. Stabin, R. B. Sparks, and E. Crowe OLINDA/EXM: The Second-Generation Personal Computer Software for Internal Dose Assessment in Nuclear Medicine J. Nucl. Med., June 1, 2005; 46(6): 1023 - 1027. [Abstract] [Full Text] [PDF]

				G. Sgouros Dosimetry of Internal Emitters J. Nucl. Med., January 1, 2005; 46(1_suppl): 18S - 27S. [Abstract] [Full Text] [PDF]

				S. Pauwels, R. Barone, S. Walrand, F. Borson-Chazot, R. Valkema, L. K. Kvols, E. P. Krenning, and F. Jamar Practical Dosimetry of Peptide Receptor Radionuclide Therapy with 90Y-Labeled Somatostatin Analogs J. Nucl. Med., January 1, 2005; 46(1_suppl): 92S - 98S. [Abstract] [Full Text] [PDF]

				R. Barone, F. Borson-Chazot, R. Valkema, S. Walrand, F. Chauvin, L. Gogou, L. K. Kvols, E. P. Krenning, F. Jamar, and S. Pauwels Patient-Specific Dosimetry in Predicting Renal Toxicity with 90Y-DOTATOC: Relevance of Kidney Volume and Dose Rate in Finding a Dose-Effect Relationship J. Nucl. Med., January 1, 2005; 46(1_suppl): 99S - 106S. [Abstract] [Full Text] [PDF]

				M. Miederer, M. R. McDevitt, G. Sgouros, K. Kramer, N.-K. V. Cheung, and D. A. Scheinberg Pharmacokinetics, Dosimetry, and Toxicity of the Targetable Atomic Generator, 225Ac-HuM195, in Nonhuman Primates J. Nucl. Med., January 1, 2004; 45(1): 129 - 137. [Abstract] [Full Text] [PDF]