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¹⁸F-FDG PET Versus CT for Evaluating the Spleen During Initial Staging of Lymphoma

¹ Division of Nuclear Medicine, Long Island Jewish Medical Center, New Hyde Park, New York
² Pediatric Radiology, Long Island Jewish Medical Center, New Hyde Park, New York

ABSTRACT

The purpose of this study was to compare ¹⁸F-FDG PET to CT for evaluating the spleen during the initial staging of lymphoma. Methods: Seven patients with newly diagnosed lymphoma underwent ¹⁸F-FDG PET and CT. Splenic uptake of ¹⁸F-FDG, diffuse or focal, greater than hepatic uptake was interpreted as consistent with tumor. CT demonstrating a positive splenic index or focal hypodensities was classified as positive for tumor. PET and CT results were compared with final diagnoses, which were confirmed surgically for 6 patients and at autopsy for 1 patient. Results: Five of 7 patients had lymphomatous involvement of the spleen. ¹⁸F-FDG PET was true-positive for all 5 patients with splenic disease and true-negative for both patients without splenic disease. CT, in contrast, was true-positive for 4 of the 5 patients with splenic disease and false-positive for the 2 patients without splenic disease. The accuracies of ¹⁸F-FDG PET and CT for evaluating the spleen were 100% and 57%, respectively. Conclusion:¹⁸F-FDG PET correctly identified all patients with and without splenic disease and was superior to CT for this purpose.

Key Words: ¹⁸F-FDG PET • lymphoma staging • splenic lymphoma

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