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Journal of Nuclear Medicine Vol. 44 No. 4 559-564
© 2003 by Society of Nuclear Medicine

Brief Communications

Radio-Tympano-Sinu-Orthesis with 186Re-Colloid: A New Treatment Modality for Chronic Otitis Media and Paranasal Mucositis

Willm U. Kampen, MD, MSc1, Godber S. Godbersen, MD, PhD2, Norbert Czech, MD1, Otto F. Besch, MD3, Winfried Brenner, MD1 and Eberhard Henze, MD, PhD1

1 Clinic of Nuclear Medicine, Christian-Albrechts-University, Kiel, Germany
2 Department of Ear, Nose and Throat, Head and Neck, Praxisklinik, Kiel, Germany
3 Department of Surgery, Teaching Hospital, Kiel University at Eckernfoerde, Eckernfoerde, Germany

ABSTRACT

This preliminary treatment trial was performed to evaluate the safety and clinical efficacy of intracavitary therapy with 186Re-colloid in patients with recurrent otitis media and paranasal sinusitis, resistant to pharmacotherapy and surgical treatment. Methods: Thirty-nine applications of 5–35 MBq 186Re-colloid into the tympanon and the paranasal sinuses were performed in 6 patients. Biodistribution and biokinetics were studied by gamma-camera imaging. Clinical success was documented 6–20 mo after therapy by each patient’s self-evaluation and by rhinootologic follow-up, using a 4-step score. Results: No harmful side effects were seen. There was good-to-excellent clinical improvement with a score of +1.44 ± 0.5 by each patient’s self-evaluation and by physicians scoring of +0.81 ± 0.9 with only negligible extracranial tracer deposition. Conclusion: This novel treatment option using intracavitary application of 186Re-colloid in chronic otitis media and sinusitis is safe and effective. The term "radio-tympano-sinu-orthesis" might be proposed analogously to the well-known radiosynoviorthesis.

Key Words: intracavitary radionuclide therapy • 186Re-sulfide • chronic otitis • eustachian tube dysfunction • paranasal sinusitis






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Copyright © 2003 by the Society of Nuclear Medicine.