HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ryu, S.-Y. Articles by Lee, K.-H. Search for Related Content PubMed PubMed Citation Articles by Ryu, S.-Y. Articles by Lee, K.-H.

Detection of Early Recurrence with ¹⁸F-FDG PET in Patients with Cervical Cancer

¹ Department of Obstetrics & Gynecology, Korea Cancer Center Hospital, Seoul, Korea
² Department of Nuclear Medicine, Korea Cancer Center Hospital, Seoul, Korea

This study investigated the feasibility of PET with ¹⁸F-FDG to evaluate retrospectively early recurrence in patients with cervical cancer. Methods: From September 1997 to March 2000, 249 patients with no evidence of cervical cancer after treatment were investigated with ¹⁸F-FDG PET. ¹⁸F-FDG PET scanning, beginning 50 min after injection of 370–555 MBq ¹⁸F-FDG, was performed. ¹⁸F-FDG uptake other than physiologic uptake was evaluated with the standardized uptake value and was analyzed by 2 observers who were unaware of CT or MRI data. CT or MRI and needle biopsies were performed to evaluate the positive lesions on ¹⁸F-FDG PET, and all patients were monitored closely for 6 mo for recurrence. Results: Of the 249 patients, 80 patients (32.1%) showed positive lesions with ¹⁸F-FDG PET, and 28 patients (11.2%) were clinically or histologically confirmed as having recurrences. Eighty-two percent of recurrence was detected within 6–18 mo after diagnosis, and 89% of recurrence occurred in Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) stage IIb and stage III patients. The sensitivity and specificity of ¹⁸F-FDG PET for detection of early recurrence were 90.3% and 76.1%, respectively. The sensitivity of ¹⁸F-FDG PET was high in mediastinal, hilar, and scalene lymph nodes, spine, and liver; however, the sensitivity was relatively low in lung, retrovesical lymph nodes, and paraaortic lymph nodes. Three false-negative cases were detected in lung, retrovesical lymph nodes, and paraaortic lymph nodes. Conclusion: ¹⁸F-FDG PET was effective in detecting early recurrences in cervical cancer patients with no evidence of disease. ¹⁸F-FDG PET may be a useful follow-up method for cervical cancer, thereby providing the patients with early opportunities for sophisticated treatments.

Key Words: ¹⁸F-FDG PET • cervical cancer • recurrence

This article has been cited by other articles:

				D. J. A. Margolis, J. M. Hoffman, R. J. Herfkens, R. B. Jeffrey, A. Quon, and S. S. Gambhir Molecular Imaging Techniques in Body Imaging Radiology, November 1, 2007; 245(2): 333 - 356. [Abstract] [Full Text] [PDF]

				B. A. Whitson, S. J. Runge, S. S. Groth, and M. A. Maddaus False-positive mediastinal lymph node activity on positron emission tomographic scan after adjuvant treatment of gynecologic malignancies J. Thorac. Cardiovasc. Surg., May 1, 2007; 133(5): 1385 - 1386. [Full Text] [PDF]

				M. A. Blake, A. Singh, B. N. Setty, J. Slattery, M. Kalra, M. M. Maher, D. V. Sahani, A. J. Fischman, and P. R. Mueller Pearls and Pitfalls in Interpretation of Abdominal and Pelvic PET-CT RadioGraphics, September 1, 2006; 26(5): 1335 - 1353. [Abstract] [Full Text] [PDF]

				M. A. Amendola, H. Hricak, D. G. Mitchell, B. Snyder, D. S. Chi, H. J. Long III, J. V. Fiorica, and C. Gatsonis Utilization of Diagnostic Studies in the Pretreatment Evaluation of Invasive Cervical Cancer in the United States: Results of Intergroup Protocol ACRIN 6651/GOG 183 J. Clin. Oncol., October 20, 2005; 23(30): 7454 - 7459. [Abstract] [Full Text] [PDF]

				N. Subhas, P. V. Patel, H. K. Pannu, H. A. Jacene, E. K. Fishman, and R. L. Wahl Imaging of Pelvic Malignancies with In-Line FDG PET-CT: Case Examples and Common Pitfalls of FDG PET RadioGraphics, July 1, 2005; 25(4): 1031 - 1043. [Abstract] [Full Text] [PDF]

				G. J. Kelloff, J. M. Hoffman, B. Johnson, H. I. Scher, B. A. Siegel, E. Y. Cheng, B. D. Cheson, J. O'Shaughnessy, K. Z. Guyton, D. A. Mankoff, et al. Progress and Promise of FDG-PET Imaging for Cancer Patient Management and Oncologic Drug Development Clin. Cancer Res., April 15, 2005; 11(8): 2785 - 2808. [Abstract] [Full Text] [PDF]

				T. Z. Belhocine 18F-FDG PET Imaging in Posttherapy Monitoring of Cervical Cancers: From Diagnosis to Prognosis J. Nucl. Med., October 1, 2004; 45(10): 1602 - 1604. [Full Text] [PDF]

				T.-C. Yen, L.-C. See, T.-C. Chang, K.-G. Huang, K.-K. Ng, S. G. Tang, Y.-C. Chang, S. Hsueh, C.-S. Tsai, J.-H. Hong, et al. Defining the Priority of Using 18F-FDG PET for Recurrent Cervical Cancer J. Nucl. Med., October 1, 2004; 45(10): 1632 - 1639. [Abstract] [Full Text] [PDF]

				P. W. Grigsby, B. A. Siegel, F. Dehdashti, J. Rader, and I. Zoberi Posttherapy [18F] Fluorodeoxyglucose Positron Emission Tomography in Carcinoma of the Cervix: Response and Outcome J. Clin. Oncol., June 1, 2004; 22(11): 2167 - 2171. [Abstract] [Full Text] [PDF]