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^99mTc-Aprotinin Scintigraphy in Amyloidosis

¹ Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
² Department of Clinical Physiology and Nuclear Medicine, Hillerød Sygehus, Hillerød, Denmark
³ Department of Haematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
⁴ Section for Radiopharmacy, Danish Medicines Agency, Copenhagen, Denmark

Changes in the amount and distribution of amyloid lesions have been difficult to monitor because they can usually be demonstrated only by evident symptoms or from a biopsy. The recent progress in the treatment of amyloidosis stresses the need for an early diagnosis and the need for noninvasive monitoring during the course of treatment. To validate ^99mTc-aprotinin scintigraphy, we studied 23 consecutive patients with known or suspected amyloidosis. Methods: ^99mTc-Aprotinin (500–700 MBq) was injected intravenously and whole-body scans, regional images, and SPECT tomograms were obtained 90 min after tracer injection. Results: Focal accumulations of ^99mTc-aprotinin were seen in different organs of 22 patients with a total of 90 lesions, of which 20 were confirmed by biopsy or autopsy. Scintigraphy revealed "silent" amyloid deposits in at least 5 patients who later developed clinical symptoms. Physiologic uptake or excretion in liver and kidneys could not be differentiated from pathologic lesions in those organs. Conclusion: ^99mTc-Aprotinin scintigraphy appears to be a fairly sensitive and specific diagnostic modality in patients with suspected amyloidosis. The technique is noninvasive, and it entails a minimal stress to the patient and is useful for detection of a wide range of lesions.

Key Words: amyloidosis • ^99mTc-aprotinin • scintigraphy

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