JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cohade, C.
Right arrow Articles by Wahl, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cohade, C.
Right arrow Articles by Wahl, R. L.
Journal of Nuclear Medicine Vol. 44 No. 11 1797-1803
© 2003 by Society of Nuclear Medicine

Clinical Investigations

Direct Comparison of 18F-FDG PET and PET/CT in Patients with Colorectal Carcinoma

Christian Cohade, MD, Medhat Osman, MD, PhD, Jeffrey Leal, BA and Richard L. Wahl, MD

Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, Maryland

The purpose of this study was to compare 18F-FDG PET and PET/CT in a population of patients with colorectal cancer. Methods: PET and PET/CT images from 45 patients (17 women, 28 men; mean age ± SD, 60.8 ± 11.1 y) with known colorectal cancer referred for PET from June to November 2001 were retrospectively reviewed. Images were acquired with a PET/CT scanner, and 68Ge attenuation correction was applied. PET images and fused 68Ge attenuation–corrected PET and CT images were independently and separately interpreted by a moderately experienced reader unaware of the clinical information. Certainty of lesion characterization was scored on a 5-point scale (0 = definitely benign, 1 = probably benign, 2 = equivocal, 3 = probably malignant, 4 = definitely malignant). Lesion location was scored on a 3-point scale (0 = uncertain, 1 = probable, 2 = definite). The presence or absence of tumor was subsequently assessed using all available clinical, pathologic, and follow-up information. Analysis was provided for lesions detected by both PET and PET/CT. Results: The frequency of equivocal and probable lesion characterization was reduced by 50% (50 to 25) with PET/CT, in comparison with PET. The frequency of definite lesion characterization was increased by 30% (84 to 109) with PET/CT. The number of definite locations was increased by 25% (92 to 115) with PET/CT. Overall correct staging increased from 78% to 89% with PET/CT on a patient-by-patient analysis. Conclusion: PET/CT imaging increases the accuracy and certainty of locating lesions in colorectal cancer. More definitely normal and definitely abnormal lesions (and fewer probable and equivocal lesions) were identified with PET/CT than with PET alone. Staging and restaging accuracy improved from 78% to 89%.

Key Words: 18F-FDG • PET/CT • PET • CT • colorectal carcinoma




This article has been cited by other articles:


Home page
 Br. J. Ophthalmol.Home page
M Kurli, K Chin, and P T Finger
Whole-body 18 FDG PET/CT imaging for lymph node and metastatic staging of conjunctival melanoma
Br. J. Ophthalmol., April 1, 2008; 92(4): 479 - 482.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
D. J. A. Margolis, J. M. Hoffman, R. J. Herfkens, R. B. Jeffrey, A. Quon, and S. S. Gambhir
Molecular Imaging Techniques in Body Imaging
Radiology, November 1, 2007; 245(2): 333 - 356.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
D. Basu, B. A. Siegel, D. J. McDonald, and B. Nussenbaum
Detection of Occult Bone Metastases From Head and Neck Squamous Cell Carcinoma: Impact of Positron Emission Tomography Computed Tomography With Fluorodeoxyglucose F 18
Arch Otolaryngol Head Neck Surg, August 1, 2007; 133(8): 801 - 805.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
A. B. Elaini, S. K. Shetty, V. M. Chapman, D. V. Sahani, G. W. Boland, A. T. Sweeney, M. M. Maher, J. T. Slattery, P. R. Mueller, and M. A. Blake
Improved Detection and Characterization of Adrenal Disease with PET-CT
RadioGraphics, May 1, 2007; 27(3): 755 - 767.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
F. H. Fahey, M. R. Palmer, K. J. Strauss, R. E. Zimmerman, R. D. Badawi, and S. T. Treves
Dosimetry and Adequacy of CT-based Attenuation Correction for Pediatric PET: Phantom Study
Radiology, April 1, 2007; 243(1): 96 - 104.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. M. Blodgett, C. C. Meltzer, and D. W. Townsend
PET/CT: Form and Function
Radiology, February 1, 2007; 242(2): 360 - 385.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
Y. Nakamoto, S. Sakamoto, T. Okada, M. Senda, T. Higashi, T. Saga, and K. Togashi
Clinical Value of Manual Fusion of PET and CT Images in Patients with Suspected Recurrent Colorectal Cancer
Am. J. Roentgenol., January 1, 2007; 188(1): 257 - 267.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
H. Schoder and M. Gonen
Screening for Cancer with PET and PET/CT: Potential and Limitations
J. Nucl. Med., January 1, 2007; 48(1_suppl): 4S - 18S.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
O. Israel and A. Kuten
Early Detection of Cancer Recurrence: 18F-FDG PET/CT Can Make a Difference in Diagnosis and Patient Care
J. Nucl. Med., January 1, 2007; 48(1_suppl): 28S - 35S.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
V. Gregoire, K. Haustermans, X. Geets, S. Roels, and M. Lonneux
PET-Based Treatment Planning in Radiotherapy: A New Standard?
J. Nucl. Med., January 1, 2007; 48(1_suppl): 68S - 77S.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J. Czernin, M. Allen-Auerbach, and H. R. Schelbert
Improvements in Cancer Staging with PET/CT: Literature-Based Evidence as of September 2006
J. Nucl. Med., January 1, 2007; 48(1_suppl): 78S - 88S.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
J. D. Berry and G. J. R. Cook
Positron emission tomography in oncology
Br. Med. Bull., December 14, 2006; (2006) ldl013v1.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
P. Veit-Haibach, C. A. Kuehle, T. Beyer, H. Stergar, H. Kuehl, J. Schmidt, G. Borsch, G. Dahmen, J. Barkhausen, A. Bockisch, et al.
Diagnostic Accuracy of Colorectal Cancer Staging With Whole-Body PET/CT Colonography
JAMA, December 6, 2006; 296(21): 2590 - 2600.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
D. L. Joyce, R. L. Wahl, P. V. Patel, R. D. Schulick, S. L. Gearhart, and M. A. Choti
Preoperative Positron Emission Tomography to Evaluate Potentially Resectable Hepatic Colorectal Metastases
Arch Surg, December 1, 2006; 141(12): 1220 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. H. Choi, W. K. Moon, J. H. Hong, K. R. Son, N. Cho, B. J. Kwon, J. J. Lee, J.-K. Chung, H. S. Min, and S. H. Park
Lymph Node Metastasis: Ultrasmall Superparamagnetic Iron Oxide-enhanced MR Imaging versus PET/CT in a Rabbit Model
Radiology, December 1, 2006; 242(1): 137 - 143.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
R. L. Korn, A. M. Yost, C. C. May, E. R. Kovalsky, K. M. Orth, T. A. Layton, and D. Drumm
Unexpected focal hypermetabolic activity in the breast: significance in patients undergoing 18F-FDG PET/CT.
Am. J. Roentgenol., July 1, 2006; 187(1): 81 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
E Goshen, T Davidson, D Aderka, and S T Zwas
PET/CT detects abdominal wall and port site metastases of colorectal carcinoma.
Br. J. Radiol., July 1, 2006; 79(943): 572 - 577.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
H Furukawa, H Ikuma, A Seki, K Yokoe, S Yuen, T Aramaki, and S Yamagushi
Positron emission tomography scanning is not superior to whole body multidetector helical computed tomography in the preoperative staging of colorectal cancer
Gut, July 1, 2006; 55(7): 1007 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
G. K. von Schulthess, H. C. Steinert, and T. F. Hany
Integrated PET/CT: Current Applications and Future Directions
Radiology, February 1, 2006; 238(2): 405 - 422.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P Veit, C Kuhle, T Beyer, H Kuehl, C U Herborn, G Borsch, H Stergar, J Barkhausen, A Bockisch, and G Antoch
Whole body positron emission tomography/computed tomography (PET/CT) tumour staging with integrated PET/CT colonography: technical feasibility and first experiences in patients with colorectal cancer
Gut, January 1, 2006; 55(1): 68 - 73.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Tatsumi, C. Cohade, Y. Nakamoto, E. K. Fishman, and R. L. Wahl
Direct Comparison of FDG PET and CT Findings in Patients with Lymphoma: Initial Experience
Radiology, December 1, 2005; 237(3): 1038 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
S Reddy, M Kurli, L B Tena, and P T Finger
PET/CT imaging: detection of choroidal melanoma
Br. J. Ophthalmol., October 1, 2005; 89(10): 1265 - 1269.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
P T Finger, M Kurli, S Reddy, L B Tena, and A C Pavlick
Whole body PET/CT for initial staging of choroidal melanoma
Br. J. Ophthalmol., October 1, 2005; 89(10): 1270 - 1274.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
H. Schoder, H. W.D. Yeung, and S. M. Larson
CT in PET/CT: Essential Features of Interpretation
J. Nucl. Med., August 1, 2005; 46(8): 1249 - 1251.
[Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
F. Gutman, J.-L. Alberini, M. Wartski, D. Vilain, E. Le Stanc, F. Sarandi, C. Corone, C. Tainturier, and A. P. Pecking
Incidental Colonic Focal Lesions Detected by FDG PET/CT
Am. J. Roentgenol., August 1, 2005; 185(2): 495 - 500.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
H. Fukunaga, M. Sekimoto, M. Ikeda, I. Higuchi, M. Yasui, I. Seshimo, O. Takayama, H. Yamamoto, M. Ohue, M. Tatsumi, et al.
Fusion Image of Positron Emission Tomography and Computed Tomography for the Diagnosis of Local Recurrence of Rectal Cancer
Ann. Surg. Oncol., July 1, 2005; 12(7): 561 - 569.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
R. E. Coleman, D. Delbeke, M. J. Guiberteau, P. S. Conti, H. D. Royal, J. C. Weinreb, B. A. Siegel, M. F. Federle, D. W. Townsend, and L. L. Berland
Concurrent PET/CT with an Integrated Imaging System: Intersociety Dialogue from the Joint Working Group of the American College of Radiology, the Society of Nuclear Medicine, and the Society of Computed Body Tomography and Magnetic Resonance
J. Nucl. Med., July 1, 2005; 46(7): 1225 - 1239.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
N. Subhas, P. V. Patel, H. K. Pannu, H. A. Jacene, E. K. Fishman, and R. L. Wahl
Imaging of Pelvic Malignancies with In-Line FDG PET-CT: Case Examples and Common Pitfalls of FDG PET
RadioGraphics, July 1, 2005; 25(4): 1031 - 1043.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
T. Ishimori, P. V. Patel, and R. L. Wahl
Detection of Unexpected Additional Primary Malignancies with PET/CT
J. Nucl. Med., May 1, 2005; 46(5): 752 - 757.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
B. F. Branstetter IV, T. M. Blodgett, L. A. Zimmer, C. H. Snyderman, J. T. Johnson, S. Raman, and C. C. Meltzer
Head and Neck Malignancy: Is PET/CT More Accurate than PET or CT Alone?
Radiology, May 1, 2005; 235(2): 580 - 586.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
T. M. Blodgett, B. Casagranda, D. W. Townsend, and C. C. Meltzer
Issues, Controversies, and Clinical Utility of Combined PET/CT Imaging: What Is the Interpreting Physician Facing?
Am. J. Roentgenol., May 1, 2005; 184(5_supp): S138 - S145.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J.-H. Kim, J. Czernin, M. S. Allen-Auerbach, B. S. Halpern, B. J. Fueger, J. R. Hecht, O. Ratib, M. E. Phelps, and W. A. Weber
Comparison Between 18F-FDG PET, In-Line PET/CT, and Software Fusion for Restaging of Recurrent Colorectal Cancer
J. Nucl. Med., April 1, 2005; 46(4): 587 - 595.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
U. Metser, E. Miller, A. Kessler, H. Lerman, G. Lievshitz, R. Oren, and E. Even-Sapir
Solid Splenic Masses: Evaluation with 18F-FDG PET/CT
J. Nucl. Med., January 1, 2005; 46(1): 52 - 59.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
T. Kazama, S. C. Faria, V. Varavithya, S. Phongkitkarun, H. Ito, and H. A. Macapinlac
FDG PET in the Evaluation of Treatment for Lymphoma: Clinical Usefulness and Pitfalls
RadioGraphics, January 1, 2005; 25(1): 191 - 207.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
G. P. Ollenberger, W. Weder, G. K. von Schulthess, and H. C. Steinert
Staging of Lung Cancer with Integrated PET-CT
N. Engl. J. Med., January 1, 2004; 350(1): 86 - 87.
[Full Text] [PDF]

Home page
 JNMHome page
H. Schoder, S. M. Larson, and H. W.D. Yeung
PET/CT in Oncology: Integration into Clinical Management of Lymphoma, Melanoma, and Gastrointestinal Malignancies
J. Nucl. Med., January 1, 2004; 45(90010): 72S - 81.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
R. L. Wahl
Why Nearly All PET of Abdominal and Pelvic Cancers Will Be Performed as PET/CT
J. Nucl. Med., January 1, 2004; 45(90010): 82S - 95.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
C. Schiepers
PET/CT in Colorectal Cancer
J. Nucl. Med., November 1, 2003; 44(11): 1804 - 1805.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2003 by the Society of Nuclear Medicine.