JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fukuchi, K.
Right arrow Articles by Ishida, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fukuchi, K.
Right arrow Articles by Ishida, Y.
Journal of Nuclear Medicine Vol. 44 No. 10 1582-1585
© 2003 by Society of Nuclear Medicine

Clinical Investigations

Visualization of Interscapular Brown Adipose Tissue Using 99mTc-Tetrofosmin in Pediatric Patients

Kazuki Fukuchi, MD1, Yasuo Ono, MD2, Yayoi Nakahata, MD2, Yoko Okada, MD2, Kohei Hayashida, MD1 and Yoshio Ishida, MD1

1 Department of Radiology, National Cardiovascular Center, Suita, Osaka, Japan
2 Department of Pediatrics, National Cardiovascular Center, Suita, Osaka, Japan

Brown adipose tissue (BAT) is a site of nonshivering thermogenesis in mammals. The mitochondria of BAT operate in an uncoupled mode and increase fatty acid oxidation to produce heat at birth. Thus, the BAT of human infants and children contains more active mitochondria than that of adults. We surmised that because 99mTc-tetrofosmin can be absorbed by functional mitochondria in the myocardium and in tumor cells, it could reveal mitochondrial function in BAT. Methods: Between January 1999 and December 2002, we retrospectively analyzed 385 consecutive studies of 99mTc-tetrofosmin uptake in pediatric patients with cardiac disorders. All patients with symmetric 99mTc-tetrofosmin accumulation within the neck and shoulder region according to planar images were selected, and the features of the uptake were analyzed. Results: Increased symmetric 99mTc-tetrofosmin uptake in the interscapular BAT was a typical profile of 65 of the 385 patients (17%). The frequency of 99mTc-tetrofosmin uptake was significantly higher in winter than in spring or summer (P < 0.05) and prominent in newborns. The frequency peaked between 0 and 2 y of age and then declined with age. Conclusion: Gamma-camera imaging with 99mTc-tetrofosmin can reveal interscapular BAT distribution in infants and children in terms of mitochondrial activity.

Key Words: 99mTc-tetrofosmin • brown adipose tissue • pediatrics




This article has been cited by other articles:


Home page
 Br. J. Radiol.Home page
A AGRAWAL, N NAIR, and N S BAGHEL
A novel approach for reduction of brown fat uptake on FDG PET
Br. J. Radiol., August 1, 2009; 82(980): 626 - 631.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
S. Goetze, W. C. Lavely, H. A. Ziessman, and R. L. Wahl
Visualization of Brown Adipose Tissue with 99mTc-Methoxyisobutylisonitrile on SPECT/CT
J. Nucl. Med., May 1, 2008; 49(5): 752 - 756.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
M. Hadi, C. C. Chen, M. Whatley, K. Pacak, and J. A. Carrasquillo
Brown Fat Imaging with 18F-6-Fluorodopamine PET/CT, 18F-FDG PET/CT, and 123I-MIBG SPECT: A Study of Patients Being Evaluated for Pheochromocytoma
J. Nucl. Med., July 1, 2007; 48(7): 1077 - 1083.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
W. A. Weber
Brown Adipose Tissue and Nuclear Medicine Imaging
J. Nucl. Med., July 1, 2004; 45(7): 1101 - 1103.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2003 by the Society of Nuclear Medicine.