| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Investigations |
1 Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea
2 Department of Neurology, College of Medicine, Seoul National University, Seoul, Korea
3 Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, Korea
The sensitivity of 18F-FDG PET to localize epileptogenic zones in frontal lobe epilepsy was evaluated by both visual assessment and statistical parametric mapping (SPM). Methods: Twenty-nine patients with frontal lobe epilepsy were examined. All patients showed good outcome after surgical resection (Engel class I or II). On pathologic examination, 22 patients had cortical dysplasia, 4 had tumors, 1 had cortical scars, and 2 had an old infarct. Hypometabolic lesions were found on 18F-FDG PET images by both visual assessment and SPM analysis. On SPM analysis, the cutoff threshold was varied and sensitivity to find epileptogenic zones was compared. Results: MRI showed structural lesions in 15 patients and normal findings in 14. 18F-FDG PET correctly localized the epileptogenic zones in 16 patients (55%) by visual assessment. The sensitivity of 18F-FDG PET was 36% in patients without structural lesions on MRI and 73% in patients with structural lesions. On SPM analysis, using an uncorrected probability value of 0.005 as the threshold, the sensitivity of SPM analysis was 66%, which was not statistically different from the sensitivity of visual assessment. The sensitivity decreased according to the decrease in probability value. Conclusion: 18F-FDG PET was sensitive in localizing epileptogenic zones by revealing hypometabolic areas in nonlesional patients with frontal lobe epilepsy as well as in lesional patients. SPM analysis showed a comparable sensitivity to visual assessment and could be used as an aid in diagnosing epileptogenic zones in frontal lobe epilepsy.
Key Words: frontal lobe epilepsy • 18F-FDG PET • statistical parametric mapping
This article has been cited by other articles:
|
|
 |
|
  J. Mbwana, M. M. Berl, E. K. Ritzl, L. Rosenberger, J. Mayo, S. Weinstein, J. A. Conry, P. L. Pearl, S. Shamim, E. N. Moore, et al. Limitations to plasticity of language network reorganization in localization related epilepsy Brain, February 1, 2009; 132(2): 347 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Poduri, A. Golja, M. Takeoka, B. F. D. Bourgeois, L. Connolly, and J. J. Riviello Jr Focal Cortical Malformations Can Show Asymmetrically Higher Uptake on Interictal Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography (PET) J Child Neurol, February 1, 2007; 22(2): 232 - 237. [Abstract] [PDF]
|
|
|
|
|
|
L. E. Jeha, I. Najm, W. Bingaman, D. Dinner, P. Widdess-Walsh, and H. Luders Surgical outcome and prognostic factors of frontal lobe epilepsy surgery Brain, February 1, 2007; 130(2): 574 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Y. Joo, E. K. Lee, W. S. Tae, and S. B. Hong Unitemporal vs Bitemporal Hypometabolism in Mesial Temporal Lobe Epilepsy Arch Neurol, July 1, 2004; 61(7): 1074 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Lee, J. C. Paeng, D. S. Lee, J. S. Lee, C. W. Oh, M. J. Cho, J.-K. Chung, and M. C. Lee Efficacy Assessment of Cerebral Arterial Bypass Surgery Using Statistical Parametric Mapping and Probabilistic Brain Atlas on Basal/Acetazolamide Brain Perfusion SPECT J. Nucl. Med., February 1, 2004; 45(2): 202 - 206. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
