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Journal of Nuclear Medicine Vol. 43 No. 9 1157-1166
© 2002 by Society of Nuclear Medicine

Clinical Investigations

The FDG Lumped Constant in Normal Human Brain

Michael M. Graham, PhD, MD1, Mark Muzi, MS2, Alexander M. Spence, MD3, Finbarr O’Sullivan, PhD2, Thomas K. Lewellen, PhD2, Jeanne M. Link, PhD2 and Kenneth A. Krohn, PhD2

1 Division of Nuclear Medicine, Department of Radiology, University of Iowa, Iowa City, Iowa
2 Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, Washington
3 Department of Neurology, University of Washington, Seattle, Washington

The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using 1-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.

Key Words: FDG • 11C-glucose • lumped constant • glucose metabolism




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