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Detection of Neuroendocrine Tumors: ^99mTc-P829 Scintigraphy Compared with ¹¹¹In-Pentetreotide Scintigraphy

¹ Nuclear Medicine Department, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France
² Nuclear Medicine Department, Centre Eugène Marquis, Rennes, France
³ Nuclear Medicine Department, Hôpital Universitaire Neuro-Cardiologique, Lyon, France
⁴ Gastroenterology Department, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France

The aim of this study was to evaluate the diagnostic value of a new somatostatin analog, ^99mTc-P829, compared with that of ¹¹¹In-pentetreotide. Methods: Forty-three patients (32 men, 11 women; age range, 24–78 y; mean age, 56 y) with biologically or histologically proven neuroendocrine tumors were prospectively included: 11 patients with Zollinger-Ellison syndrome, 16 patients with carcinoid tumors, and 16 patients with other types of functioning (n = 6) or nonfunctioning (n = 10) endocrine tumors. ¹¹¹In-Pentetreotide planar images (head, chest, abdomen, and pelvis) were obtained 4 and 24 h after injection of 10 µg somatostatin analog labeled with 148 ± 17 MBq ¹¹¹In, and SPECT was performed 24 h after injection. Similar ^99mTc-P829 planar images were obtained at 1, 4–6, and 24 h after injection of 50 µg peptide labeled with 991.6 ± 187.59 MBq ^99mTc. Abdominal SPECT was performed 4–6 h after injection. Results: ¹¹¹In-Pentetreotide detected 203 tumoral sites in 39 (91%) of 43 patients, whereas ^99mTc-P829 detected 77 sites in 28 (65%) of 43 patients (P < 0.005). In the liver, 129 sites (in 24 patients) were detected by ¹¹¹In-pentetreotide scintigraphy and 34 sites (in 10 patients) were detected by ^99mTc-P829 scintigraphy. Conclusion: In patients with endocrine tumors, the detection rate of ^99mTc-P829 scintigraphy was lower than that of ¹¹¹In-pentetreotide scintigraphy, which appeared to be more sensitive, especially for liver metastases.

Key Words: somatostatin receptor scintigraphy • ^99mTc-P829 scintigraphy • endocrine tumors

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